The reaction between sulfites and nitric oxide or proposed carriers of nitric oxide (nitrosylated bovine serum albumin and S-nitrosoglutathione) was investigated as a potential source of the adverse effects of sulfites on biological systems. Rapid reaction occurred between sulfites and all of these reagents. Also, the ability of nitric oxide and these carriers of nitric oxide to inhibit platelet aggregation was reversed by low concentrations of sulfites. Counteraction of nitric oxide's ability to function in cell signaling processes may be a major cause of sulfite toxicity.
Bibliographical noteFunding Information:
This research was supported in part by grant GM38819 from the National Institutes of Health. S.B.H. was supported by an administrative supplement described in NIH Guide for Grants and Contracts, Vol. 21, No. 3; P.T. 34, 44, FF; K.W. 0720005, 0710030. We would like to thank Dr. Bridgette Barry and Dr. Alan B. Hooper for use of instrumentation and Dr. Joseph Warthesen and Dr. Gregory M. Vercellotti for reading the manuscript.
- Nitric oxide
- Nitric oxide derivative
- Platelet aggregation
- Respiratory disease
- Sulfite toxicity