Reaction of nitric oxide and its derivatives with sulfites: A possible role in sulfite toxicity

Stephen B. Harvey, Gary L. Nelsestuen

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The reaction between sulfites and nitric oxide or proposed carriers of nitric oxide (nitrosylated bovine serum albumin and S-nitrosoglutathione) was investigated as a potential source of the adverse effects of sulfites on biological systems. Rapid reaction occurred between sulfites and all of these reagents. Also, the ability of nitric oxide and these carriers of nitric oxide to inhibit platelet aggregation was reversed by low concentrations of sulfites. Counteraction of nitric oxide's ability to function in cell signaling processes may be a major cause of sulfite toxicity.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalBBA - Molecular Cell Research
Issue number1
StatePublished - May 29 1995



  • Nitric oxide
  • Nitric oxide derivative
  • Platelet aggregation
  • Respiratory disease
  • Signaling
  • Sulfite toxicity

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