Reaction of electron rich heterocycles with electrophiles. Formylation of indoles via thiomethylation

Eyup Akgün, Mustafa Tunali

Research output: Contribution to journalArticlepeer-review

Abstract

The formylation of indoles 1 by dithiocarbenium‐ions 2 is discussed. The reaction proceeds to thioacetals 4 under mild conditions. Longer reaction times yield bisindolylmonomethylcyanines 5–6. Generally, the reaction is inhibited by the presence of electron‐withdrawing groups at the pyrrol nucleus of indole 1, e.g. an acetyl group.

Original languageEnglish (US)
Pages (from-to)1473-1476
Number of pages4
JournalJournal of Heterocyclic Chemistry
Volume27
Issue number5
DOIs
StatePublished - Jan 1 1990

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