Reaction of α-halogen substituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine: New route to trifluoroacetyl-containing heterocycles

Liliya M. Kacharova, Igor I. Gerus, Alexey D. Kacharov

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The reaction of α-halosubstituted β-ethoxyvinyl trifluomethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo [1,2-a]pyridine and 3-halo-1,1,1,-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalJournal of Fluorine Chemistry
Volume117
Issue number2
DOIs
StatePublished - Oct 28 2002
Externally publishedYes

Keywords

  • Amination
  • Bicyclic heterocyclic compounds
  • Cyclization
  • Enones
  • Fluorinated α-enamino ketones

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