Reaction of α-halogen substituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine: New route to trifluoroacetyl-containing heterocycles

Liliya M. Kacharova; Igor I. Gerus; Alexey D. Kacharov

doi:10.1016/S0022-1139(02)00190-2

Reaction of α-halogen substituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine: New route to trifluoroacetyl-containing heterocycles

Liliya M. Kacharova, Igor I. Gerus, Alexey D. Kacharov

Advanced Materials Center

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The reaction of α-halosubstituted β-ethoxyvinyl trifluomethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo [1,2-a]pyridine and 3-halo-1,1,1,-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent.

Original language	English (US)
Pages (from-to)	193-197
Number of pages	5
Journal	Journal of Fluorine Chemistry
Volume	117
Issue number	2
DOIs	https://doi.org/10.1016/S0022-1139(02)00190-2
State	Published - Oct 28 2002

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Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

Amination
Bicyclic heterocyclic compounds
Cyclization
Enones
Fluorinated α-enamino ketones

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10.1016/S0022-1139(02)00190-2

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title = "Reaction of α-halogen substituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine: New route to trifluoroacetyl-containing heterocycles",

abstract = "The reaction of α-halosubstituted β-ethoxyvinyl trifluomethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo [1,2-a]pyridine and 3-halo-1,1,1,-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent.",

keywords = "Amination, Bicyclic heterocyclic compounds, Cyclization, Enones, Fluorinated α-enamino ketones",

author = "Kacharova, {Liliya M.} and Gerus, {Igor I.} and Kacharov, {Alexey D.}",

year = "2002",

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doi = "10.1016/S0022-1139(02)00190-2",

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TY - JOUR

T1 - Reaction of α-halogen substituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine

T2 - New route to trifluoroacetyl-containing heterocycles

AU - Kacharova, Liliya M.

AU - Gerus, Igor I.

AU - Kacharov, Alexey D.

PY - 2002/10/28

Y1 - 2002/10/28

N2 - The reaction of α-halosubstituted β-ethoxyvinyl trifluomethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo [1,2-a]pyridine and 3-halo-1,1,1,-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent.

AB - The reaction of α-halosubstituted β-ethoxyvinyl trifluomethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo [1,2-a]pyridine and 3-halo-1,1,1,-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent.

KW - Amination

KW - Bicyclic heterocyclic compounds

KW - Cyclization

KW - Enones

KW - Fluorinated α-enamino ketones

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DO - 10.1016/S0022-1139(02)00190-2

M3 - Article

AN - SCOPUS:0037190662

SN - 0022-1139

VL - 117

SP - 193

EP - 197

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

IS - 2

ER -

Reaction of α-halogen substituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine: New route to trifluoroacetyl-containing heterocycles

Abstract

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Keywords

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