Reaction of α-Acetoxy-N-nitrosopiperidine with Deoxyguanosine: Oxygen-Dependent formation of 4-Oxo-2-pentenal and a 1,N²-Ethenodeoxyguanosine Adduct

Keyphrases

• 2′-Deoxyguanosine 100%
• Oxygen Dependence 100%
• Acetoxy 100%
• N-nitrosopiperidine 100%
• N-nitrosopyrrolidine 60%
• Metabolic Activation 40%
• Carcinogenic Activity 20%
• Nitrosamines 20%
• DNA Adducts 20%
• Carcinogen 20%
• Purine 20%
• Incubation 20%
• High-performance Liquid Chromatography 20%
• Buffer pH 20%
• DNA Binding 20%
• Hydroxylation 20%
• Phosphate Buffer 20%
• 1H nuclear Magnetic Resonance (1H NMR) 20%
• Five-membered 20%
• Six-membered 20%
• Solvolysis 20%
• UV Detection 20%
• Liver Carcinogen 20%
• Percentage Yield 20%

Chemistry

• 2-Pentenal 100%
• N-Nitrosopiperidine 100%
• formation 100%
• N-Nitrosopyrrolidine 60%
• Metabolic Activation 40%
• Chemistry 20%
• Buffer Solution 20%
• 1H NMR Spectroscopy 20%
• Liquid Chromatography 20%
• Carcinogenic 20%
• Solvolysis 20%
• Heterocyclic Compound 20%
• Purine 20%
• Nitrosamine 20%
• hydroxylation 20%
• DNA 20%
• DNA Adduct 20%
• DNA Binding 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Deoxyguanosine 100%
• N Nitrosopyrrolidine 75%
• Carcinogen 50%
• Nitrosamine 25%
• Buffer 25%
• Purine 25%