RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)

Narendra K. Tripathy; Gunda I. Georg

doi:10.1016/j.tetlet.2004.04.164

RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)

Narendra K. Tripathy
, Gunda I. Georg

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

An efficient total synthesis of cryptophycin-24 (arenastatin A) is reported, which features two novel synthetic strategies, the use of a RCM reaction to form the macrocycle, and the introduction of the styrene epoxide moiety prior to the macrocyclization reaction.

Original language	English (US)
Pages (from-to)	5309-5311
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	27
DOIs	https://doi.org/10.1016/j.tetlet.2004.04.164
State	Published - Jun 28 2004

Bibliographical note

Funding Information:
We thank the National Institutes of Health (NCI) for financial support (CA 70369).

Keywords

Antitumor agents
Cryptophycins
RCM
Total synthesis

Publisher link

10.1016/j.tetlet.2004.04.164

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title = "RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)",

abstract = "An efficient total synthesis of cryptophycin-24 (arenastatin A) is reported, which features two novel synthetic strategies, the use of a RCM reaction to form the macrocycle, and the introduction of the styrene epoxide moiety prior to the macrocyclization reaction.",

keywords = "Antitumor agents, Cryptophycins, RCM, Total synthesis",

author = "Tripathy, \{Narendra K.\} and Georg, \{Gunda I.\}",

note = "Funding Information: We thank the National Institutes of Health (NCI) for financial support (CA 70369). ",

year = "2004",

month = jun,

day = "28",

doi = "10.1016/j.tetlet.2004.04.164",

language = "English (US)",

volume = "45",

pages = "5309--5311",

journal = "Tetrahedron Letters",

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number = "27",

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T1 - RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)

AU - Tripathy, Narendra K.

AU - Georg, Gunda I.

N1 - Funding Information: We thank the National Institutes of Health (NCI) for financial support (CA 70369).

PY - 2004/6/28

Y1 - 2004/6/28

N2 - An efficient total synthesis of cryptophycin-24 (arenastatin A) is reported, which features two novel synthetic strategies, the use of a RCM reaction to form the macrocycle, and the introduction of the styrene epoxide moiety prior to the macrocyclization reaction.

AB - An efficient total synthesis of cryptophycin-24 (arenastatin A) is reported, which features two novel synthetic strategies, the use of a RCM reaction to form the macrocycle, and the introduction of the styrene epoxide moiety prior to the macrocyclization reaction.

KW - Antitumor agents

KW - Cryptophycins

KW - RCM

KW - Total synthesis

UR - https://www.scopus.com/pages/publications/2942578216

UR - https://www.scopus.com/pages/publications/2942578216#tab=citedBy

U2 - 10.1016/j.tetlet.2004.04.164

DO - 10.1016/j.tetlet.2004.04.164

M3 - Article

AN - SCOPUS:2942578216

SN - 0040-4039

VL - 45

SP - 5309

EP - 5311

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 27

ER -

RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)

Abstract

Bibliographical note

Keywords

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