Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study:: A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium

Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)

doi:10.1097/mpa.0000000000002079

Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium

Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

Original language	English (US)
Pages (from-to)	568-574
Number of pages	7
Journal	Pancreas
Volume	51
Issue number	6
DOIs	https://doi.org/10.1097/mpa.0000000000002079
State	Published - Jul 1 2022

Bibliographical note

Funding Information:
The study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) under award numbers U01 DK127367 (G.T., M.B.), U01 DK127377 (A.E.P., F.G.S.T., D.Y.), U01 DK127378 (C.Y.), U01 DK127382 (J.J.E., E.F., T.T.), U01 DK127384 (A.M.D., V.C., J.L.M., M.W.), U01 DK127388 (P.A.H., G.I.P., D.L.C., K.M.D., P.J.L.), U01 DK127392 (C.F.), U01 DK127395 (W.J.P.), U01 DK127400 (E.A., V.A., R.R.K., V.S., A.Z.), U01 DK127403 (J.B., M.K., S.J.P., S.S.V.), and U01 DK127404 (C.G., R.K., C.S.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Keywords

AP - acute pancreatitis
CP - chronic pancreatitis
DCC - data coordinating center
DM - diabetes mellitus
DREAM - Diabetes RElated to Acute pancreatitis and its Mechanisms
FSIGTT - frequently sampled intravenous glucose tolerance testing
MMTT - mixed meal tolerance testing
OGTT - oral glucose tolerance testing
T1DAPC - Type 1 Diabetes in Acute Pancreatitis Consortium
autoantibody
beta cell
epidemiology
insulin
pancreatogenic diabetes
type 3c diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1097/mpa.0000000000002079

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@article{b77e6a8aaea34663a8c9fe31b37f7877,

title = "Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study:: A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium",

abstract = "Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.",

keywords = "AP - acute pancreatitis, CP - chronic pancreatitis, DCC - data coordinating center, DM - diabetes mellitus, DREAM - Diabetes RElated to Acute pancreatitis and its Mechanisms, FSIGTT - frequently sampled intravenous glucose tolerance testing, MMTT - mixed meal tolerance testing, OGTT - oral glucose tolerance testing, T1DAPC - Type 1 Diabetes in Acute Pancreatitis Consortium, autoantibody, beta cell, epidemiology, insulin, pancreatogenic diabetes, type 3c diabetes",

author = "{Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)} and Hart, {Phil A.} and Papachristou, {Georgios I.} and Park, {Walter G.} and Dyer, {Anne Marie} and Chinchilli, {Vernon M.} and Elham Afghani and Akshintala, {Venkata S.} and Andersen, {Dana K.} and Buxbaum, {James L.} and Conwell, {Darwin L.} and Dungan, {Kathleen M.} and Easler, {Jeffrey J.} and Fogel, {Evan L.} and Greenbaum, {Carla J.} and Kalyani, {Rita R.} and Murray Korc and Richard Kozarek and Laughlin, {Maren R.} and Lee, {Peter J.} and Maranki, {Jennifer L.} and Pandol, {Stephen J.} and Phillips, {Anna Evans} and Jose Serrano and Singh, {Vikesh K.} and Cate Speake and Temel Tirkes and Toledo, {Frederico G.S.} and Guru Trikudanathan and Vege, {Santhi Swaroop} and Ming Wang and Cemal Yazici and Atif Zaheer and Forsmark, {Christopher E.} and Bellin, {Melena D.} and Dhiraj Yadav",

note = "Funding Information: The study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) under award numbers U01 DK127367 (G.T., M.B.), U01 DK127377 (A.E.P., F.G.S.T., D.Y.), U01 DK127378 (C.Y.), U01 DK127382 (J.J.E., E.F., T.T.), U01 DK127384 (A.M.D., V.C., J.L.M., M.W.), U01 DK127388 (P.A.H., G.I.P., D.L.C., K.M.D., P.J.L.), U01 DK127392 (C.F.), U01 DK127395 (W.J.P.), U01 DK127400 (E.A., V.A., R.R.K., V.S., A.Z.), U01 DK127403 (J.B., M.K., S.J.P., S.S.V.), and U01 DK127404 (C.G., R.K., C.S.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",

year = "2022",

month = jul,

day = "1",

doi = "10.1097/mpa.0000000000002079",

language = "English (US)",

volume = "51",

pages = "568--574",

journal = "Pancreas",

issn = "0885-3177",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study:

T2 - A Prospective Cohort Study from the Type 1 Diabetes in Acute Pancreatitis Consortium

AU - Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)

AU - Hart, Phil A.

AU - Papachristou, Georgios I.

AU - Park, Walter G.

AU - Dyer, Anne Marie

AU - Chinchilli, Vernon M.

AU - Afghani, Elham

AU - Akshintala, Venkata S.

AU - Andersen, Dana K.

AU - Buxbaum, James L.

AU - Conwell, Darwin L.

AU - Dungan, Kathleen M.

AU - Easler, Jeffrey J.

AU - Fogel, Evan L.

AU - Greenbaum, Carla J.

AU - Kalyani, Rita R.

AU - Korc, Murray

AU - Kozarek, Richard

AU - Laughlin, Maren R.

AU - Lee, Peter J.

AU - Maranki, Jennifer L.

AU - Pandol, Stephen J.

AU - Phillips, Anna Evans

AU - Serrano, Jose

AU - Singh, Vikesh K.

AU - Speake, Cate

AU - Tirkes, Temel

AU - Toledo, Frederico G.S.

AU - Trikudanathan, Guru

AU - Vege, Santhi Swaroop

AU - Wang, Ming

AU - Yazici, Cemal

AU - Zaheer, Atif

AU - Forsmark, Christopher E.

AU - Bellin, Melena D.

AU - Yadav, Dhiraj

N1 - Funding Information: The study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) under award numbers U01 DK127367 (G.T., M.B.), U01 DK127377 (A.E.P., F.G.S.T., D.Y.), U01 DK127378 (C.Y.), U01 DK127382 (J.J.E., E.F., T.T.), U01 DK127384 (A.M.D., V.C., J.L.M., M.W.), U01 DK127388 (P.A.H., G.I.P., D.L.C., K.M.D., P.J.L.), U01 DK127392 (C.F.), U01 DK127395 (W.J.P.), U01 DK127400 (E.A., V.A., R.R.K., V.S., A.Z.), U01 DK127403 (J.B., M.K., S.J.P., S.S.V.), and U01 DK127404 (C.G., R.K., C.S.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © Wolters Kluwer Health, Inc. All rights reserved.

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

AB - Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

KW - AP - acute pancreatitis

KW - CP - chronic pancreatitis

KW - DCC - data coordinating center

KW - DM - diabetes mellitus

KW - DREAM - Diabetes RElated to Acute pancreatitis and its Mechanisms

KW - FSIGTT - frequently sampled intravenous glucose tolerance testing

KW - MMTT - mixed meal tolerance testing

KW - OGTT - oral glucose tolerance testing

KW - T1DAPC - Type 1 Diabetes in Acute Pancreatitis Consortium

KW - autoantibody

KW - beta cell

KW - epidemiology

KW - insulin

KW - pancreatogenic diabetes

KW - type 3c diabetes

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UR - http://www.scopus.com/inward/citedby.url?scp=85139572032&partnerID=8YFLogxK

U2 - 10.1097/mpa.0000000000002079

DO - 10.1097/mpa.0000000000002079

M3 - Article

C2 - 36206460

AN - SCOPUS:85139572032

SN - 0885-3177

VL - 51

SP - 568

EP - 574

JO - Pancreas

JF - Pancreas

IS - 6

ER -