Rate-independent constructs for chemical computation

Phillip Senum, Marc Riedel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a collection of computational modules implemented with chemical reactions: an inverter, an incrementer, a decrementer, a copier, a comparator, and a multiplier. Unlike previous schemes for chemical computation, ours produces designs that are dependent only on coarse rate categories for the reactions (fast vs. slow). Given such categories, the computation is exact and independent of the specific reaction rates. We validate our designs through stochastic simulations of the chemical kinetics. Although conceptual for the time being, our methodology has potential applications in domains of synthetic biology such as biochemical sensing and drug delivery. We are exploring DNA-based computation via strand displacement as a possible experimental chassis.

Original languageEnglish (US)
Title of host publicationPacific Symposium on Biocomputing 2011, PSB 2011
Pages326-337
Number of pages12
StatePublished - Dec 1 2011
Event16th Pacific Symposium on Biocomputing, PSB 2011 - Kohala Coast, HI, United States
Duration: Jan 3 2011Jan 7 2011

Publication series

NamePacific Symposium on Biocomputing 2011, PSB 2011

Other

Other16th Pacific Symposium on Biocomputing, PSB 2011
CountryUnited States
CityKohala Coast, HI
Period1/3/111/7/11

Keywords

  • chemical reaction networks
  • molecular computing
  • molecular programming
  • synthetic biology

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