Rapidly Progressive and Catastrophic Calciphylaxis After Mechanical Valve Replacement: An Anticoagulation Dilemma

Philippe F. Nyembo; Keith E Eidman; Mengistu A Simegn; Andrew W. Shaffer; Gautam R Shroff

doi:10.1016/j.jaccas.2022.07.034

Rapidly Progressive and Catastrophic Calciphylaxis After Mechanical Valve Replacement: An Anticoagulation Dilemma

Philippe F. Nyembo, Keith E Eidman, Mengistu A Simegn, Andrew W. Shaffer, Gautam R Shroff

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Warfarin is the only approved anticoagulant after mechanical valve replacement, but it is a well described risk factor for calciphylaxis among patients with end-stage kidney disease. Our patient with end-stage kidney disease rapidly developed calciphylaxis after dual mechanical valve replacement in association with warfarin initiation, posing significant challenges in clinical management and a fatal outcome. (Level of Difficulty: Intermediate.)

Original language	English (US)
Pages (from-to)	1319-1323
Number of pages	5
Journal	JACC: Case Reports
Volume	4
Issue number	19
DOIs	https://doi.org/10.1016/j.jaccas.2022.07.034
State	Published - Oct 5 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors

Keywords

anticoagulation
disorders of calcium disease
thrombosis
valve replacement

PubMed: MeSH publication types

Case Reports

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaccas.2022.07.034

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abstract = "Warfarin is the only approved anticoagulant after mechanical valve replacement, but it is a well described risk factor for calciphylaxis among patients with end-stage kidney disease. Our patient with end-stage kidney disease rapidly developed calciphylaxis after dual mechanical valve replacement in association with warfarin initiation, posing significant challenges in clinical management and a fatal outcome. (Level of Difficulty: Intermediate.)",

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AU - Nyembo, Philippe F.

AU - Eidman, Keith E

AU - Simegn, Mengistu A

AU - Shaffer, Andrew W.

AU - Shroff, Gautam R

PY - 2022/10/5

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AB - Warfarin is the only approved anticoagulant after mechanical valve replacement, but it is a well described risk factor for calciphylaxis among patients with end-stage kidney disease. Our patient with end-stage kidney disease rapidly developed calciphylaxis after dual mechanical valve replacement in association with warfarin initiation, posing significant challenges in clinical management and a fatal outcome. (Level of Difficulty: Intermediate.)

KW - anticoagulation

KW - disorders of calcium disease

KW - thrombosis

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ER -

Rapidly Progressive and Catastrophic Calciphylaxis After Mechanical Valve Replacement: An Anticoagulation Dilemma

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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