Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation

Alexander J. Grenning, Jonathan H. Boyce, John A. Porco

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Polyprenylated acylphloroglucinols (PPAPs) are structurally complex natural products with promising biological activities. Herein, we present a biosynthesis-inspired, diversity-oriented synthesis approach for rapid construction of PPAP analogs via double decarboxylative allylation (DcA) of acylphloroglucinol scaffolds to access allyl-desoxyhumulones followed by dearomative conjunctive allylic alkylation (DCAA).

Original languageEnglish (US)
Pages (from-to)11799-11804
Number of pages6
JournalJournal of the American Chemical Society
Volume136
Issue number33
DOIs
StatePublished - Aug 20 2014
Externally publishedYes

Fingerprint

Dive into the research topics of 'Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation'. Together they form a unique fingerprint.

Cite this