Rapid infusion of sodium valproate in acutely ill children

Angela K. Birnbaum, Robert L. Kriel, Shani K. Norberg, Beverly S. Wical, Duy N. Le, Ilo E. Leppik, James C. Cloyd

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The purpose of this study was to investigate the clinical safety of sodium valproate and total and unbound valproic acid plasma concentrations after rapid infusion in hospitalized, acutely ill children. Four children (5-15 years) completed the study. Sodium valproate doses (8.3-15.4 mg/kg) were administered in ≤15 minutes. No clinically significant changes in vital signs were observed nor were there any significant adverse events. Both total and unbound valproic acid concentrations were higher at 0.5 hour than at pre-infusion or 6 hours after infusion. Rapid administration of valproate to acutely ill patients can be done safely. Unbound valproic acid concentrations in acutely ill as compared with relatively healthy epilepsy patients were higher and could not be predicted based on their total pre-infusion valproic acid concentrations.Birnbaum AK, Kriel RL, Norberg SK, Wical BS, Le DN, Leppik IE, Cloyd JC. Rapid infusion of sodium valproate in acutely ill children.

Original languageEnglish (US)
Pages (from-to)300-303
Number of pages4
JournalPediatric Neurology
Issue number4
StatePublished - Apr 2003

Bibliographical note

Funding Information:
This study was supported by Abbott Laboratories and by NIH Grant NINDS P50NS16308.


  • Pharmacokinetic
  • Rapid infusion
  • Valproate


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