Rapid High‐Efficiency Hemodialysis

Allan Collins, Karen Ilstrup, Ginger Hanson, Robert Berkseth, Prakash Keshaviah

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Abstract: Reductions in treatment time are attractive for patients and dialysis centers. However, there are concerns related to treatment adequacy and increased intradialytic symptoms. Treatment times were progressively reduced in 12 stable patients on standard 4‐h acetate hemodialysis, solute clearances being increased proportionately, until the tolerance limit manifested by increased complications or 2.5 h of treatment was reached. Once shortened schedules (mean reduction ˜31%) were achieved, a 2‐month surveillance period was initiated, followed by 2 additional months of bicarbonate therapy, treatment time being unchanged. Rapid bicarbonate hemodialysis was associated with a significantly lower incidence of hypotension, nausea, and vomiting than rapid acetate or standard acetate therapies. Fluid removal was comparable with that of standard treatment, and serum chemistry levels remained stable. Based on the success of these studies treatment times have been reduced in > 200 patients with high‐efficiency bicarbonate therapy for long‐term evaluations.

Original languageEnglish (US)
Pages (from-to)185-188
Number of pages4
JournalArtificial Organs
Issue number3
StatePublished - Jun 1986


  • Bicarbonate
  • Hemodialysis
  • High blood flow rate
  • High efficiency
  • Large surface area dialyzers
  • Ultrafiltration control


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