Rapid detection of powassan virus in a patient with encephalitis by metagenomic sequencing

Anne Piantadosi; Sanjat Kanjilal; Vijay Ganesh; Arjun Khanna; Emily P. Hyle; Jonathan Rosand; Tyler Bold; Hayden C. Metsky; Jacob Lemieux; Michael J. Leone; Lisa Freimark; Christian B. Matranga; Gordon Adams; Graham McGrath; Siavash Zamirpour; Sam Telford; Eric Rosenberg; Tracey Cho; Matthew P. Frosch; Marcia B. Goldberg; Shibani S. Mukerji; Pardis C. Sabeti

doi:10.1093/cid/cix792

Rapid detection of powassan virus in a patient with encephalitis by metagenomic sequencing

Anne Piantadosi
, Sanjat Kanjilal
, Vijay Ganesh
, Arjun Khanna
, Emily P. Hyle
, Jonathan Rosand
, Tyler Bold
, Hayden C. Metsky
, Jacob Lemieux
, Michael J. Leone
, Lisa Freimark
, Christian B. Matranga
, Gordon Adams
, Graham McGrath
, Siavash Zamirpour
, Sam Telford
, Eric Rosenberg
, Tracey Cho
, Matthew P. Frosch
, Marcia B. Goldberg

Shibani S. Mukerji, Pardis C. Sabeti

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.

Original language	English (US)
Pages (from-to)	789-792
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	66
Issue number	5
DOIs	https://doi.org/10.1093/cid/cix792
State	Published - Mar 2018

Bibliographical note

Publisher Copyright:
© The Author(s) 2017.

Keywords

Encephalitis
Metagenomic sequencing
Powassan virus

Publisher link

10.1093/cid/cix792

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850433

Find It

Find It at U of M Libraries

Cite this

Piantadosi, A., Kanjilal, S., Ganesh, V., Khanna, A., Hyle, E. P., Rosand, J., Bold, T., Metsky, H. C., Lemieux, J., Leone, M. J., Freimark, L., Matranga, C. B., Adams, G., McGrath, G., Zamirpour, S., Telford, S., Rosenberg, E., Cho, T., Frosch, M. P., ... Sabeti, P. C. (2018). Rapid detection of powassan virus in a patient with encephalitis by metagenomic sequencing. Clinical Infectious Diseases, 66(5), 789-792. https://doi.org/10.1093/cid/cix792

Piantadosi, A, Kanjilal, S, Ganesh, V, Khanna, A, Hyle, EP, Rosand, J, Bold, T, Metsky, HC, Lemieux, J, Leone, MJ, Freimark, L, Matranga, CB, Adams, G, McGrath, G, Zamirpour, S, Telford, S, Rosenberg, E, Cho, T, Frosch, MP, Goldberg, MB, Mukerji, SS & Sabeti, PC 2018, 'Rapid detection of powassan virus in a patient with encephalitis by metagenomic sequencing', Clinical Infectious Diseases, vol. 66, no. 5, pp. 789-792. https://doi.org/10.1093/cid/cix792

@article{c54efdb06e1543969e82f74c0bbe214a,

title = "Rapid detection of powassan virus in a patient with encephalitis by metagenomic sequencing",

abstract = "We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.",

keywords = "Encephalitis, Metagenomic sequencing, Powassan virus",

author = "Anne Piantadosi and Sanjat Kanjilal and Vijay Ganesh and Arjun Khanna and Hyle, \{Emily P.\} and Jonathan Rosand and Tyler Bold and Metsky, \{Hayden C.\} and Jacob Lemieux and Leone, \{Michael J.\} and Lisa Freimark and Matranga, \{Christian B.\} and Gordon Adams and Graham McGrath and Siavash Zamirpour and Sam Telford and Eric Rosenberg and Tracey Cho and Frosch, \{Matthew P.\} and Goldberg, \{Marcia B.\} and Mukerji, \{Shibani S.\} and Sabeti, \{Pardis C.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2017.",

year = "2018",

month = mar,

doi = "10.1093/cid/cix792",

language = "English (US)",

volume = "66",

pages = "789--792",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "5",

}

TY - JOUR

T1 - Rapid detection of powassan virus in a patient with encephalitis by metagenomic sequencing

AU - Piantadosi, Anne

AU - Kanjilal, Sanjat

AU - Ganesh, Vijay

AU - Khanna, Arjun

AU - Hyle, Emily P.

AU - Rosand, Jonathan

AU - Bold, Tyler

AU - Metsky, Hayden C.

AU - Lemieux, Jacob

AU - Leone, Michael J.

AU - Freimark, Lisa

AU - Matranga, Christian B.

AU - Adams, Gordon

AU - McGrath, Graham

AU - Zamirpour, Siavash

AU - Telford, Sam

AU - Rosenberg, Eric

AU - Cho, Tracey

AU - Frosch, Matthew P.

AU - Goldberg, Marcia B.

AU - Mukerji, Shibani S.

AU - Sabeti, Pardis C.

PY - 2018/3

Y1 - 2018/3

N2 - We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.

AB - We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.

KW - Encephalitis

KW - Metagenomic sequencing

KW - Powassan virus

UR - https://www.scopus.com/pages/publications/85044131973

UR - https://www.scopus.com/pages/publications/85044131973#tab=citedBy

U2 - 10.1093/cid/cix792

DO - 10.1093/cid/cix792

M3 - Article

C2 - 29020227

AN - SCOPUS:85044131973

SN - 1058-4838

VL - 66

SP - 789

EP - 792

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 5

ER -

Rapid detection of powassan virus in a patient with encephalitis by metagenomic sequencing

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this