Abstract
We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.
Original language | English (US) |
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Pages (from-to) | 789-792 |
Number of pages | 4 |
Journal | Clinical Infectious Diseases |
Volume | 66 |
Issue number | 5 |
DOIs | |
State | Published - Mar 2018 |
Bibliographical note
Funding Information:Potential conflicts of interest. S. T. reports consultation on tick-borne disease diagnostics with Oxford Immunotec, Fuller Laboratories, and Meridian Biosciences. E. R. reports consultation with T2 Biosystems and TBS Technologies. M. F. reports a sponsored research grant from Biogen. All other authors declare no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
Funding Information:
We would like to thank Asim Ahmed, MD, and Daniel Park, PhD, for valuable comments on the manuscript, and Cormac Kinsella, Simon Ye, Katherine Siddle, PhD, and Andreas Gnirke, PhD, for expert technical advice. This work was supported by the National Institutes of Health (KL2 TR001100 to A. P., T32 AI007061 to S. K., and T32 AG000222 to S. S. M.), a Massachusetts General Hospital Department of Neurology SPARK Award to S. S. M. and T. C., and a generous Broadnext10 gift from the Broad Institute.
Funding Information:
Financial support. This work was supported by the National Institutes of Health (KL2 TR001100 to A. P., T32 AI007061 to S. K., and T32 AG000222 to S. S. M.), a Massachusetts General Hospital Department of Neurology SPARK Award to S. S. M. and T. C., and a generous Broadnext10 gift from the Broad Institute.
Publisher Copyright:
© The Author(s) 2017.
Keywords
- Encephalitis
- Metagenomic sequencing
- Powassan virus