Rapid detection of powassan virus in a patient with encephalitis by metagenomic sequencing

Anne Piantadosi, Sanjat Kanjilal, Vijay Ganesh, Arjun Khanna, Emily P. Hyle, Jonathan Rosand, Tyler Bold, Hayden C. Metsky, Jacob Lemieux, Michael J. Leone, Lisa Freimark, Christian B. Matranga, Gordon Adams, Graham McGrath, Siavash Zamirpour, Sam Telford, Eric Rosenberg, Tracey Cho, Matthew P. Frosch, Marcia B. GoldbergShibani S. Mukerji, Pardis C. Sabeti

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.

Original languageEnglish (US)
Pages (from-to)789-792
Number of pages4
JournalClinical Infectious Diseases
Volume66
Issue number5
DOIs
StatePublished - Mar 2018

Bibliographical note

Publisher Copyright:
© The Author(s) 2017.

Keywords

  • Encephalitis
  • Metagenomic sequencing
  • Powassan virus

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