Rapid administration of high-dose human antibody Fab fragments to dogs: Pharmacokinetics and toxicity

Keyphrases

• Pharmacokinetics 100%
• High Dose 100%
• Human Antibody 100%
• Rapid Administration 100%
• Antibody Fab Fragment 100%
• Drug Overdose 50%
• Nephrotoxicity 33%
• Antibody Fragment 33%
• Light Microscopy 16%
• Electron Microscopy 16%
• Histology 16%
• Beagle 16%
• Specific Antibodies 16%
• Potential Toxicity 16%
• Hemodynamic Effects 16%
• Fab Fragment 16%
• Elimination Half-life 16%
• Urinary Albumin Excretion 16%
• Oliguria 16%
• Creatinine Clearance 16%
• Urinary Protein Excretion 16%
• Terminal Half-life 16%
• Serum Creatinine Concentration 16%
• Renal Clearance 16%
• Renal Histology 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Drug Overdose 100%
• Immunoglobulin F(ab) Fragment 100%
• Pharmacokinetics 100%
• Nephrotoxicity 66%
• Creatinine 66%
• Elimination 33%
• Electron Microscopy 33%
• Beagle 33%
• Oliguria 33%
• Antibodies 33%

Veterinary Science and Veterinary Medicine

• Dog 100%
• Creatinine 25%
• Rat 12%
• Hemodynamic 12%