Abstract
The two-step: Chroman-3-ones are important intermediates for organic synthesis and medicinal chemistry. However, their syntheses require multiple steps and are not efficient. By using gold-catalyzed alkyne oxidation, this versatile heterocycle can be prepared in only two steps from readily available phenols and with mostly high efficiencies (see scheme).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1915-1918 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 8 |
| DOIs | |
| State | Published - Feb 20 2012 |
| Externally published | Yes |
Keywords
- carbenes
- gold
- heterocycles
- homogeneous catalysis
- oxidation