Rapid access to chroman-3-ones through gold-catalyzed oxidation of propargyl aryl ethers

Yanzhao Wang, Kegong Ji, Sylvester Lan, Liming Zhang

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

The two-step: Chroman-3-ones are important intermediates for organic synthesis and medicinal chemistry. However, their syntheses require multiple steps and are not efficient. By using gold-catalyzed alkyne oxidation, this versatile heterocycle can be prepared in only two steps from readily available phenols and with mostly high efficiencies (see scheme).

Original languageEnglish (US)
Pages (from-to)1915-1918
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number8
DOIs
StatePublished - Feb 20 2012

Keywords

  • carbenes
  • gold
  • heterocycles
  • homogeneous catalysis
  • oxidation

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