Vorzeitiger Abbruch randomisierter kontrollierter Studien: Vorteilsbedingter Therapieeffekt

L. A. Kluth; M. Rink; S. A. Ahyai; M. Fisch; S. F. Shariat; P. Dahm

doi:10.1007/s00120-013-3144-2

Vorzeitiger Abbruch randomisierter kontrollierter Studien: Vorteilsbedingter Therapieeffekt

Translated title of the contribution: Randomized controlled trials terminated prematurely: Beneficial therapy effects

L. A. Kluth, M. Rink, S. A. Ahyai, M. Fisch, S. F. Shariat, P. Dahm

Urology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Randomized controlled trials (RCTs) stopped prematurely for beneficial therapy effects are becoming increasingly more prevalent in the urological literature and often receive great attention in the public and medical media. Urologists who practice evidence-based medicine should be aware of the potential bias and the different reasons why and how early termination of RCTs can and will affect the results. This review provides insights into the challenges clinical urologists face by interpreting the results of prematurely terminated RCTs.

Translated title of the contribution	Randomized controlled trials terminated prematurely: Beneficial therapy effects
Original language	German
Pages (from-to)	1080-1083
Number of pages	4
Journal	Urologe - Ausgabe A
Volume	52
Issue number	8
DOIs	https://doi.org/10.1007/s00120-013-3144-2
State	Published - Aug 2013

Bibliographical note

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

Bias, epidemiological
Evidence-based medicine
Study termination, premature
Therapy effect

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10.1007/s00120-013-3144-2

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AU - Rink, M.

AU - Ahyai, S. A.

AU - Fisch, M.

AU - Shariat, S. F.

AU - Dahm, P.

PY - 2013/8

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AB - Randomized controlled trials (RCTs) stopped prematurely for beneficial therapy effects are becoming increasingly more prevalent in the urological literature and often receive great attention in the public and medical media. Urologists who practice evidence-based medicine should be aware of the potential bias and the different reasons why and how early termination of RCTs can and will affect the results. This review provides insights into the challenges clinical urologists face by interpreting the results of prematurely terminated RCTs.

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KW - Therapy effect

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Vorzeitiger Abbruch randomisierter kontrollierter Studien: Vorteilsbedingter Therapieeffekt

Abstract

Bibliographical note

Keywords

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