Randomized clinical trials of dental bleaching - Compliance with the CONSORT Statement: A systematic review

Alessandro Dourado Loguercio, Bianca Medeiros Maran, Taíse Alessandra Hanzen, Alexandra Mara de Paula, Jorge Perdigão, Alessandra Reis

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

We reviewed the literature to evaluate: a) The compliance of randomized clinical trials (RCTs) on bleaching with the CONSORT; and b) the risk of bias of these studies using the Cochrane Collaboration risk of bias tool (CCRT). We searched the Cochrane Library, PubMed and other electronic databases, to find RCTs focused on bleaching (or whitening). The articles were evaluated in compliance with CONSORT in a scale: 0 = no description, 1 = poor description and 2 = adequate description. Descriptive analyses of the number of studies by journal, follow-up period, country and quality assessments were performed with CCRT for assessing risk of bias in RCTs. 185 RCTs were included for assessment. More than 30% of the studies received score 0 or 1. Protocol, flow chart, allocation concealment and sample size were more critical items, as 80% of the studies scored 0. The overall CONSORT score for the included studies was 16.7 ± 5.4 points, which represents 52.2% of the maximum CONSORT score. A significant difference among journal, country and period of time was observed (p < 0.02). Only 7.6% of the studies were judged at "low" risk; 62.1% were classified as "unclear"; and 30.3% as "high" risk of bias. The adherence of RCTs evaluating bleaching materials and techniques to the CONSORT is still low with unclear/high risk of bias.

Original languageEnglish (US)
Pages (from-to)100-132
Number of pages33
JournalBrazilian Oral Research
Volume31
DOIs
StatePublished - Aug 1 2017

Bibliographical note

Funding Information:
The authors would like to thanks to Mr. Amelia Falcone, Brand Manager from Compendium for kindly provide us some papers from the Compendium Continuing Education in Dentistry including in this review. This study was partially supported by CAPES and National Council for Scientific and Technological Development (CNPq) under grants 304104/2013-9 and 305588/2014-1.

Keywords

  • Dental sensitivity
  • Tooth bleaching

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