Radiation Treatment Decreases Bone Cancer Pain, Osteolysis and Tumor Size

M. Goblirsch; W. Mathews; C. Lynch; P. Alaei; B. J. Gerbi; P. W. Mantyh; D. R. Clohisy

doi:10.1667/RR3108

Radiation Treatment Decreases Bone Cancer Pain, Osteolysis and Tumor Size

M. Goblirsch, W. Mathews, C. Lynch, P. Alaei, B. J. Gerbi, P. W. Mantyh, D. R. Clohisy

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Abstract

Radiotherapy is the cornerstone of palliative treatment for primary bone cancer in animals and metastatic bone cancer in humans. However, the mechanism(s) responsible for pain relief after irradiation is unknown. To identify the mechanism through which radiation treatment decreases bone cancer pain, the effect of radiation on mice with painful bone cancer was studied. Analysis of the effects of a 20-Gy treatment on localized sites of painful bone cancers was performed through assessments of animal behavior, radiographs and histological analysis. The findings indicated that radiation treatment reduced bone pain and supported reduced cancer burden and reduced osteolysis as mechanisms through which radiation reduces bone cancer pain.

Original language	English (US)
Pages (from-to)	228-234
Number of pages	7
Journal	Radiation research
Volume	161
Issue number	2
DOIs	https://doi.org/10.1667/RR3108
State	Published - Feb 2004

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title = "Radiation Treatment Decreases Bone Cancer Pain, Osteolysis and Tumor Size",

abstract = "Radiotherapy is the cornerstone of palliative treatment for primary bone cancer in animals and metastatic bone cancer in humans. However, the mechanism(s) responsible for pain relief after irradiation is unknown. To identify the mechanism through which radiation treatment decreases bone cancer pain, the effect of radiation on mice with painful bone cancer was studied. Analysis of the effects of a 20-Gy treatment on localized sites of painful bone cancers was performed through assessments of animal behavior, radiographs and histological analysis. The findings indicated that radiation treatment reduced bone pain and supported reduced cancer burden and reduced osteolysis as mechanisms through which radiation reduces bone cancer pain.",

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AU - Goblirsch, M.

AU - Mathews, W.

AU - Lynch, C.

AU - Alaei, P.

AU - Gerbi, B. J.

AU - Mantyh, P. W.

AU - Clohisy, D. R.

PY - 2004/2

Y1 - 2004/2

N2 - Radiotherapy is the cornerstone of palliative treatment for primary bone cancer in animals and metastatic bone cancer in humans. However, the mechanism(s) responsible for pain relief after irradiation is unknown. To identify the mechanism through which radiation treatment decreases bone cancer pain, the effect of radiation on mice with painful bone cancer was studied. Analysis of the effects of a 20-Gy treatment on localized sites of painful bone cancers was performed through assessments of animal behavior, radiographs and histological analysis. The findings indicated that radiation treatment reduced bone pain and supported reduced cancer burden and reduced osteolysis as mechanisms through which radiation reduces bone cancer pain.

AB - Radiotherapy is the cornerstone of palliative treatment for primary bone cancer in animals and metastatic bone cancer in humans. However, the mechanism(s) responsible for pain relief after irradiation is unknown. To identify the mechanism through which radiation treatment decreases bone cancer pain, the effect of radiation on mice with painful bone cancer was studied. Analysis of the effects of a 20-Gy treatment on localized sites of painful bone cancers was performed through assessments of animal behavior, radiographs and histological analysis. The findings indicated that radiation treatment reduced bone pain and supported reduced cancer burden and reduced osteolysis as mechanisms through which radiation reduces bone cancer pain.

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Radiation Treatment Decreases Bone Cancer Pain, Osteolysis and Tumor Size

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