Abstract
Racemic and homochiral sodium ibuprofen were characterized by thermal analysis and powder X-ray diffractometry. The melting point phase diagram was constructed and thermodynamic calculation was performed. In contrast to racemic ibuprofen, which is a racemic compound, racemic sodium ibuprofen forms both a racemic conglomerate (termed the γ-form) as well as two polymorphic racemic compounds, α and β, which are less stable monotropes. From the supercooled liquid, α and β crystallized along with the original γ-form. Forms α and β are "enantiotropically related" with a transition temperature between 75° and 113°C, but can be considered to be metastable monotropes of the racemic conglomerate, the stable γ-form.
Original language | English (US) |
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Pages (from-to) | 1356-1366 |
Number of pages | 11 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 92 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2003 |
Bibliographical note
Funding Information:We thank the Graduate School of the University of Minnesota for a doctoral dissertation fellowship for G. G. Z. Zhang.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
Keywords
- Conglomerate
- Differential scanning calorimetry
- Enantiomer
- Enantiotropy
- Monotropy
- Phase diagram
- Polymorphism
- Powder X-ray diffractometry
- Racemic compound
- Sodium ibuprofen