Race-Related Differences in Left Ventricular Structural and Functional Remodeling in Response to Increased Afterload: The ARIC Study

Miguel M. Fernandes-Silva, Amil M. Shah, Sheila Hegde, Alexandra Goncalves, Brian Claggett, Susan Cheng, Wilson Nadruz, Dalane W. Kitzman, Suma H. Konety, Kunihiro Matsushita, Thomas Mosley, Carolyn S P Lam, Barry A. Borlaug, Scott D. Solomon

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Objectives The aim of this study was to evaluate racial differences in arterial elastance (Ea), which reflects the arterial afterload faced by the left ventricle, and its associations with cardiac structure and function. The hypothesis under study was that the left ventricle in blacks displays heightened afterload sensitivity compared with whites. Background Chronic increasing in arterial afterload may be an important trigger for left ventricular (LV) remodeling and dysfunction that lead to heart failure. Racial differences in the predisposition to heart failure are well described, but the underlying mechanisms remain unclear. Methods In total, 5,727 community-based, older ARIC (Atherosclerosis Risk In Community) study participants (22% black) who underwent echocardiography between 2011 and 2013 were studied. Results Blacks were younger (mean age 75 ± 5 years vs. 76 ± 5 years), were more frequently female (66% vs. 57%), and had higher prevalence rates of obesity (46% vs. 31%), hypertension (94% vs. 80%), and diabetes mellitus (47% vs. 34%) than whites. Adjusting for these baseline differences, Ea was higher among blacks (1.96 ± 0.01 mm Hg/ml vs. 1.80 ± 0.01 mm Hg/ml). In blacks, Ea was associated with greater LV remodeling (LV mass index, β = 3.21 ± 0.55 g/m2, p < 0.001) and higher LV filling pressures (E/e′ ratio, β = 0.42 ± 0.11, p < 0.001). These relationships were not observed in whites (LV mass, β = 0.16 ± 0.32 g/m2, p = 0.61, p for interaction <0.001; E/e′ ratio, β = −0.32 ± 0.06, p < 0.001, p for interaction <0.001). Conclusions These community-based data suggest that black Americans display heightened afterload sensitivity as a stimulus for LV structural and functional remodeling, which may contribute to their greater risk for heart failure compared with white Americans.

Original languageEnglish (US)
Pages (from-to)157-165
Number of pages9
JournalJACC: Heart Failure
Issue number3
StatePublished - Mar 1 2017

Bibliographical note

Publisher Copyright:
© 2017 American College of Cardiology Foundation


  • arterial elastance
  • cardiac remodeling
  • hypertension
  • left ventricular hypertrophy
  • race


Dive into the research topics of 'Race-Related Differences in Left Ventricular Structural and Functional Remodeling in Response to Increased Afterload: The ARIC Study'. Together they form a unique fingerprint.

Cite this