Race and vitamin D binding protein gene polymorphisms modify the association of 25-hydroxyvitamin D and incident heart failure. The ARIC (Atherosclerosis Risk in Communities) Study

Pamela L. Lutsey, Erin D. Michos, Jeffrey R. Misialek, James S. Pankow, Laura Loehr, Elizabeth Selvin, Jared P. Reis, Myron Gross, John H. Eckfeldt, Aaron R. Folsom

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Objectives: This study sought to determine if low serum 25-hydroxyvitamin D (25[OH]D) is associated with incident heart failure (HF) and if the association is: 1) partly mediated by traditional cardiovascular risk factors; 2) stronger among whites than blacks; and 3) stronger among those genetically predisposed to having high levels of vitamin D binding protein (DBP). Background: Suboptimal 25(OH)D is a potential cardiovascular risk factor. Methods: A total of 12,215 ARIC (Atherosclerosis Risk in Communities) study participants free of HF at baseline (1990 to 1992; median age, 56; 24% black) were followed through 2010. Total serum 25(OH)D was measured at baseline using liquid chromatography-mass spectrometry. Incident HF events were identified by a hospital discharge code of ICD9-428 and parallel International Classification of Diseases codes for HF deaths. Results: During 21 years of follow-up, 1,799 incident HF events accrued. The association between 25(OH)D and HF varied by race (p-interaction= 0.02). Among whites, risk was 2-fold higher for those in the lowest (≤17 ng/ml) versus highest (≥31 ng/ml) quintile of 25(OH)D. The association was attenuated but remained significant with covariate adjustment. In blacks there was no overall association. In both races, those with low 25(OH)D and the rs7041 G allele, which predisposes to high DBP, were at greater risk (p-interaction= 0.01). Conclusions: Low serum 25(OH)D was independently associated with incident HF among whites, but not among blacks. However, in both races, low 25(OH)D was associated with HF risk among those genetically predisposed to high DBP. These findings provide novel insight into metabolic differences that may underlie racial variation in the association between 25(OH)D and cardiovascular risk.

Original languageEnglish (US)
Pages (from-to)347-356
Number of pages10
JournalJACC: Heart Failure
Volume3
Issue number5
DOIs
StatePublished - May 1 2015

Bibliographical note

Funding Information:
The ARIC study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). Reagents for the C-reactive protein and serum albumin assays were donated by the manufacturers. Genotyping was supported through the National Heart, Lung, and Blood Institute CARe (Candidate Gene Resource) grant (N01-HC-65226). Dr. Lutsey has received grant support from the National Institutes of Health National Heart, Lung, and Blood Institute (R01 HL103706) and the National Institutes of Health Office of Dietary Supplements (R01 HL103706-S1). Dr. Selvin has received grant support from the National Institute of Diabetes and Digestive and Kidney Diseases ( R01 DK089174 ). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Publisher Copyright:
© 2015 American College of Cardiology Foundation.

Keywords

  • ARIC
  • Heart failure
  • Race
  • Vitamin D
  • Vitamin D binding protein

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