Quinoxalines block the mechanism of directional selectivity in ganglion cells of the rabbit retina

Ethan D. Cohen, Robert F. Miller

Research output: Contribution to journalArticlepeer-review

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Abstract

Direction selectivity is a receptive field property displayed by neurons throughout the visual system. Previous experiments have concentrated on the role of lateral connections that use γ-aminobutyric acid and acetylcholine. We have examined the role of excitatory amino acid receptors on direction- selective ganglion cell function in the rabbit retina. Application of the quinoxalines, a group of kainate/α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor antagonists, selectively blocked the directional-selectivity mechanism, leaving cells responsive to both directions of movement. In contrast, direction selectivity was unaffected by N-methyl-D-aspartate receptor antagonists or L-2-amino-4-phosphonobutyric acid. Large reductions in acetylcholine release by starburst amacrine cells appear to parallel losses of direction selectivity observed in the quinoxalines. These results shed additional insights into the mechanism of direction selectivity.

Original languageEnglish (US)
Pages (from-to)1127-1131
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number4
DOIs
StatePublished - Feb 14 1995

Keywords

  • 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo-f-quinoxaline
  • 2-amino- 4-phosphonobutyric acid
  • excitatory amino acids
  • starburst
  • α-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid receptor

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