Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G₂/M arrest and apoptosis

Keyphrases

• Breast Cancer Cells 100%
• Lapatinib 100%
• Apoptosis 100%
• Cancer Cell Growth 100%
• Quercetin-3-methyl Ether 100%
• G2-M Arrest 100%
• Resistant Breast Cancer 100%
• Natural Compounds 25%
• Resistant Cells 25%
• Clinical Oncology 12%
• Human Epidermal Growth Factor Receptor 2 (HER2) 12%
• Breast Cancer Patients 12%
• Therapeutic Agents 12%
• Cyclin D1 (CCND1) 12%
• Covalent Inhibitor 12%
• Anticancer Activity 12%
• Growth Inhibition 12%
• Western Blot 12%
• Unresolved Issues 12%
• Cyclin-dependent Kinase 1 (CDK1) 12%
• Checkpoint Kinase 1 (CHK1) 12%
• HER2-positive Breast Cancer 12%
• Cdc25 12%
• Caspase-7 12%
• ERK Pathway 12%
• G1 Phase 12%
• Low Toxicity 12%
• Highly Active 12%
• AKT Pathway 12%
• Poly(ADP-ribose) Polymerase 12%
• Cyclin B1 12%
• Cleaved caspase-3 12%
• Oral Small Molecules 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Lapatinib 100%
• Breast Cancer 100%
• Cancer Growth 100%
• Isorhamnetin 100%
• Western Blot 12%
• Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer 12%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 12%
• Natural Product 12%
• Cyclin D1 12%
• Caspase 7 12%
• Cyclin B1 12%
• Caspase 3 12%
• Epidermal Growth Factor Receptor 12%
• Protein Kinase B 12%