Quantitative single breath-hold renal arterial spin labeling imaging at 7T

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To evaluate the feasibility of quantitative single breath-hold renal arterial spin labeling (ASL) imaging at 7T. Methods: A single-shot fast spin echo FAIR (flow-sensitive alternating inversion recovery) method was used to perform two studies. First, a multi-delay perfusion study was performed to estimate the spin labeling temporal bolus width achievable with a local transceiver array coil at 7T. Second, with a conservatively defined bolus width, a quantitative perfusion study was performed using the single subtraction approach. To address issues of (Formula presented.) inhomogeneity/efficiency and excessive short-term specific absorption rates, various strategies were used, such as dynamic radiofrequency shimming and optimization. Results: A conservative temporal bolus width of 600 ms determined from the multi-delay study was applied for single-subtraction imaging to measure the renal blood flow in the cortex and medulla: 303 ± 31.8 and 91.3 ± 15.2 (mL/100 g/min), respectively. The estimated spatial and temporal signal-to-noise ratios of renal perfusion measurements were 3.8 ± 0.7 and 2.4 ± 0.6 for the cortex, and 2.2 ± 0.6 and 1.4 ± 0.2 for the medulla. Conclusion: With proper management of field strength specific challenges, quantitative renal ASL imaging can be achieved at 7T within a single breath-hold. Magn Reson Med 79:815–825, 2018.

Original languageEnglish (US)
Pages (from-to)815-825
Number of pages11
JournalMagnetic resonance in medicine
Volume79
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Perfusion
Kidney
Renal Circulation
Signal-To-Noise Ratio

Keywords

  • 7T
  • arterial spin labeling (ASL)
  • kidneys
  • magnetic resonance imaging (MRI)
  • renal perfusion or renal blood flow (RBF)
  • ultrahigh field (UHF)

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

@article{e818640e25124d219e8e1b473d170026,
title = "Quantitative single breath-hold renal arterial spin labeling imaging at 7T",
abstract = "Purpose: To evaluate the feasibility of quantitative single breath-hold renal arterial spin labeling (ASL) imaging at 7T. Methods: A single-shot fast spin echo FAIR (flow-sensitive alternating inversion recovery) method was used to perform two studies. First, a multi-delay perfusion study was performed to estimate the spin labeling temporal bolus width achievable with a local transceiver array coil at 7T. Second, with a conservatively defined bolus width, a quantitative perfusion study was performed using the single subtraction approach. To address issues of (Formula presented.) inhomogeneity/efficiency and excessive short-term specific absorption rates, various strategies were used, such as dynamic radiofrequency shimming and optimization. Results: A conservative temporal bolus width of 600 ms determined from the multi-delay study was applied for single-subtraction imaging to measure the renal blood flow in the cortex and medulla: 303 ± 31.8 and 91.3 ± 15.2 (mL/100 g/min), respectively. The estimated spatial and temporal signal-to-noise ratios of renal perfusion measurements were 3.8 ± 0.7 and 2.4 ± 0.6 for the cortex, and 2.2 ± 0.6 and 1.4 ± 0.2 for the medulla. Conclusion: With proper management of field strength specific challenges, quantitative renal ASL imaging can be achieved at 7T within a single breath-hold. Magn Reson Med 79:815–825, 2018.",
keywords = "7T, arterial spin labeling (ASL), kidneys, magnetic resonance imaging (MRI), renal perfusion or renal blood flow (RBF), ultrahigh field (UHF)",
author = "Xiufeng Li and Auerbach, {Edward J} and {Van de Moortele}, Pierre-Francois and Kamil Ugurbil and Greg Metzger",
year = "2018",
month = "2",
day = "1",
doi = "10.1002/mrm.26742",
language = "English (US)",
volume = "79",
pages = "815--825",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Quantitative single breath-hold renal arterial spin labeling imaging at 7T

AU - Li, Xiufeng

AU - Auerbach, Edward J

AU - Van de Moortele, Pierre-Francois

AU - Ugurbil, Kamil

AU - Metzger, Greg

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Purpose: To evaluate the feasibility of quantitative single breath-hold renal arterial spin labeling (ASL) imaging at 7T. Methods: A single-shot fast spin echo FAIR (flow-sensitive alternating inversion recovery) method was used to perform two studies. First, a multi-delay perfusion study was performed to estimate the spin labeling temporal bolus width achievable with a local transceiver array coil at 7T. Second, with a conservatively defined bolus width, a quantitative perfusion study was performed using the single subtraction approach. To address issues of (Formula presented.) inhomogeneity/efficiency and excessive short-term specific absorption rates, various strategies were used, such as dynamic radiofrequency shimming and optimization. Results: A conservative temporal bolus width of 600 ms determined from the multi-delay study was applied for single-subtraction imaging to measure the renal blood flow in the cortex and medulla: 303 ± 31.8 and 91.3 ± 15.2 (mL/100 g/min), respectively. The estimated spatial and temporal signal-to-noise ratios of renal perfusion measurements were 3.8 ± 0.7 and 2.4 ± 0.6 for the cortex, and 2.2 ± 0.6 and 1.4 ± 0.2 for the medulla. Conclusion: With proper management of field strength specific challenges, quantitative renal ASL imaging can be achieved at 7T within a single breath-hold. Magn Reson Med 79:815–825, 2018.

AB - Purpose: To evaluate the feasibility of quantitative single breath-hold renal arterial spin labeling (ASL) imaging at 7T. Methods: A single-shot fast spin echo FAIR (flow-sensitive alternating inversion recovery) method was used to perform two studies. First, a multi-delay perfusion study was performed to estimate the spin labeling temporal bolus width achievable with a local transceiver array coil at 7T. Second, with a conservatively defined bolus width, a quantitative perfusion study was performed using the single subtraction approach. To address issues of (Formula presented.) inhomogeneity/efficiency and excessive short-term specific absorption rates, various strategies were used, such as dynamic radiofrequency shimming and optimization. Results: A conservative temporal bolus width of 600 ms determined from the multi-delay study was applied for single-subtraction imaging to measure the renal blood flow in the cortex and medulla: 303 ± 31.8 and 91.3 ± 15.2 (mL/100 g/min), respectively. The estimated spatial and temporal signal-to-noise ratios of renal perfusion measurements were 3.8 ± 0.7 and 2.4 ± 0.6 for the cortex, and 2.2 ± 0.6 and 1.4 ± 0.2 for the medulla. Conclusion: With proper management of field strength specific challenges, quantitative renal ASL imaging can be achieved at 7T within a single breath-hold. Magn Reson Med 79:815–825, 2018.

KW - 7T

KW - arterial spin labeling (ASL)

KW - kidneys

KW - magnetic resonance imaging (MRI)

KW - renal perfusion or renal blood flow (RBF)

KW - ultrahigh field (UHF)

UR - http://www.scopus.com/inward/record.url?scp=85019065593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019065593&partnerID=8YFLogxK

U2 - 10.1002/mrm.26742

DO - 10.1002/mrm.26742

M3 - Article

C2 - 28488274

AN - SCOPUS:85019065593

VL - 79

SP - 815

EP - 825

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -