Quantitative multiparametric MRI of ovarian cancer

Jori S. Carter, Joseph S. Koopmeiners, Jessica E. Kuehn-Hajder, Gregory J. Metzger, Navneeth Lakkadi, Levi S. Downs, Patrick J. Bolan

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Purpose: To identify parameters associated with ovarian malignancy using multiparametric quantitative magnetic resonance imaging (MRI). Materials and Methods: After Institutional Review Board (IRB) approval, women with ovarian masses underwent preoperative imaging with 3 T MRI. Dynamic contrast-enhanced (DCE)-MRI with pharmacokinetic modeling, quantitative T2 mapping, and diffusion-weighted imaging with quantitative mapping of the water diffusion parameters were performed. Ovarian masses had one or more discreet regions of interest, categorized as cystic or solid, and histologically diagnosed as benign or malignant. Mean region of interest (ROI) values were compared between benign and malignant masses using generalized estimating equations. In addition, we compared classification accuracy for the mean ROI value to a combination of histogram characteristics (standard deviation, skewness, and kurtosis) from T2 map ROIs using logistic regression and ROC curve. The significance level was P = 0.05. Results: Several DCE-MRI parameters differentiated solid benign from malignant masses. Toft's rate constant (kep) was significantly higher in malignant masses (P < 0.001), as well as quantitative T2 values (P = 0.003), and signal intensity on T2 weighted imaging (P = 0.008). A linear combination of the mean, standard deviation, skewness, and kurtosis of T2 within solid regions (area under the curve [AUC] 0.90) provided better classification accuracy than the mean of T2 alone (AUC 0.81). Conclusion: Quantitative parameters from DCE-MRI and T2 mapping can differentiate benign from malignant ovarian masses.

Original languageEnglish (US)
Pages (from-to)1501-1509
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Issue number6
StatePublished - Dec 2013


  • investigative techniques
  • magnetic resonance imaging
  • methods
  • neoplasms
  • ovary

Center for Magnetic Resonance Research (CMRR) tags

  • CTR


Dive into the research topics of 'Quantitative multiparametric MRI of ovarian cancer'. Together they form a unique fingerprint.

Cite this