Quantitative imaging of energy expenditure in human brain

Xiao Hong Zhu; Hongyan Qiao; Fei Du; Qiang Xiong; Xiao Liu; Xiaoliang Zhang; Kamil Ugurbil; Wei Chen

doi:10.1016/j.neuroimage.2012.02.013

Quantitative imaging of energy expenditure in human brain

Xiao Hong Zhu, Hongyan Qiao, Fei Du, Qiang Xiong, Xiao Liu, Xiaoliang Zhang, Kamil Ugurbil, Wei Chen

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

Despite the essential role of the brain energy generated from ATP hydrolysis in supporting cortical neuronal activity and brain function, it is challenging to noninvasively image and directly quantify the energy expenditure in the human brain. In this study, we applied an advanced in vivo ³¹P MRS imaging approach to obtain regional cerebral metabolic rates of high-energy phosphate reactions catalyzed by ATPase (CMR _ATPase) and creatine kinase (CMR _CK), and to determine CMR _ATPase and CMR _CK in pure gray mater (GM) and white mater (WM), respectively. It was found that both ATPase and CK rates are three times higher in GM than WM; and CMR _CK is seven times higher than CMR _ATPase in GM and WM. Among the total brain ATP consumption in the human cortical GM and WM, 77% of them are used by GM in which approximately 96% is by neurons. A single cortical neuron utilizes approximately 4.7billion ATPs per second in a resting human brain. This study demonstrates the unique utility of in vivo ³¹P MRS imaging modality for direct imaging of brain energy generated from ATP hydrolysis, and provides new insights into the human brain energetics and its role in supporting neuronal activity and brain function.

Original language	English (US)
Pages (from-to)	2107-2117
Number of pages	11
Journal	NeuroImage
Volume	60
Issue number	4
DOIs	https://doi.org/10.1016/j.neuroimage.2012.02.013
State	Published - May 1 2012

Bibliographical note

Funding Information:
This work was supported in part by National Institute of Health grants: NS057560 , NS041262 , NS041262S1 , NS070839 , NS070839S1 , HL050470 , P41 RR08079 , P41 EB015894 and P30 NS057091 ; and the WM KECK Foundation .

Keywords

Adenosine triphosphate (ATP)
Brain energy
Cerebral metabolic rate of ATP production
Human brain
In vivo P MRS
P magnetization transfer

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10.1016/j.neuroimage.2012.02.013

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title = "Quantitative imaging of energy expenditure in human brain",

abstract = "Despite the essential role of the brain energy generated from ATP hydrolysis in supporting cortical neuronal activity and brain function, it is challenging to noninvasively image and directly quantify the energy expenditure in the human brain. In this study, we applied an advanced in vivo 31P MRS imaging approach to obtain regional cerebral metabolic rates of high-energy phosphate reactions catalyzed by ATPase (CMR ATPase) and creatine kinase (CMR CK), and to determine CMR ATPase and CMR CK in pure gray mater (GM) and white mater (WM), respectively. It was found that both ATPase and CK rates are three times higher in GM than WM; and CMR CK is seven times higher than CMR ATPase in GM and WM. Among the total brain ATP consumption in the human cortical GM and WM, 77% of them are used by GM in which approximately 96% is by neurons. A single cortical neuron utilizes approximately 4.7billion ATPs per second in a resting human brain. This study demonstrates the unique utility of in vivo 31P MRS imaging modality for direct imaging of brain energy generated from ATP hydrolysis, and provides new insights into the human brain energetics and its role in supporting neuronal activity and brain function.",

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note = "Funding Information: This work was supported in part by National Institute of Health grants: NS057560 , NS041262 , NS041262S1 , NS070839 , NS070839S1 , HL050470 , P41 RR08079 , P41 EB015894 and P30 NS057091 ; and the WM KECK Foundation . ",

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AU - Zhu, Xiao Hong

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AU - Xiong, Qiang

AU - Liu, Xiao

AU - Zhang, Xiaoliang

AU - Ugurbil, Kamil

AU - Chen, Wei

N1 - Funding Information: This work was supported in part by National Institute of Health grants: NS057560 , NS041262 , NS041262S1 , NS070839 , NS070839S1 , HL050470 , P41 RR08079 , P41 EB015894 and P30 NS057091 ; and the WM KECK Foundation .

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N2 - Despite the essential role of the brain energy generated from ATP hydrolysis in supporting cortical neuronal activity and brain function, it is challenging to noninvasively image and directly quantify the energy expenditure in the human brain. In this study, we applied an advanced in vivo 31P MRS imaging approach to obtain regional cerebral metabolic rates of high-energy phosphate reactions catalyzed by ATPase (CMR ATPase) and creatine kinase (CMR CK), and to determine CMR ATPase and CMR CK in pure gray mater (GM) and white mater (WM), respectively. It was found that both ATPase and CK rates are three times higher in GM than WM; and CMR CK is seven times higher than CMR ATPase in GM and WM. Among the total brain ATP consumption in the human cortical GM and WM, 77% of them are used by GM in which approximately 96% is by neurons. A single cortical neuron utilizes approximately 4.7billion ATPs per second in a resting human brain. This study demonstrates the unique utility of in vivo 31P MRS imaging modality for direct imaging of brain energy generated from ATP hydrolysis, and provides new insights into the human brain energetics and its role in supporting neuronal activity and brain function.

AB - Despite the essential role of the brain energy generated from ATP hydrolysis in supporting cortical neuronal activity and brain function, it is challenging to noninvasively image and directly quantify the energy expenditure in the human brain. In this study, we applied an advanced in vivo 31P MRS imaging approach to obtain regional cerebral metabolic rates of high-energy phosphate reactions catalyzed by ATPase (CMR ATPase) and creatine kinase (CMR CK), and to determine CMR ATPase and CMR CK in pure gray mater (GM) and white mater (WM), respectively. It was found that both ATPase and CK rates are three times higher in GM than WM; and CMR CK is seven times higher than CMR ATPase in GM and WM. Among the total brain ATP consumption in the human cortical GM and WM, 77% of them are used by GM in which approximately 96% is by neurons. A single cortical neuron utilizes approximately 4.7billion ATPs per second in a resting human brain. This study demonstrates the unique utility of in vivo 31P MRS imaging modality for direct imaging of brain energy generated from ATP hydrolysis, and provides new insights into the human brain energetics and its role in supporting neuronal activity and brain function.

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ER -

Quantitative imaging of energy expenditure in human brain

Abstract

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Keywords

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