Quantitative I-123-IMP brain SPECT and neuropsychological testing in AIDS dementia

C. C. Kuni, F. S. Rhame, M. J. Meier, M. C. Foehse, R. B. Loewenson, C. P. Benjamin, Lee, R. J. Boudreau, R. P. duCret

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We performed I-123-IMP SPECT brain imaging on seven mildly demented AIDS patients and seven normal subjects. In an attempt to detect and quantitate regions of decreased I-123-IMP uptake, pixel intensity histograms of normalized SPECT images at the basal ganglia level were analyzed for the fraction of pixels in the lowest quartile of the intensity range. This fraction (F) averaged 17.5% (S.D. = 4.6) in the AIDS group and 12.6% (S.D. = 5.1) in the normal group (p < .05). Six of the AIDS patients underwent neuropsychological testing (NPT). NPT showed the patients to have a variety of mild abnormalities. Regression analysis of NPT scores versus F yielded a correlation coefficient of .80 (p < .05). We conclude that analysis of I-123-IMP SPECT image pixel intensity distribution is potentially sensitive in detecting abnormalities associated with AIDS dementia and may correlate with the severity of dementia as measured by NPT.

Original languageEnglish (US)
Pages (from-to)174-177
Number of pages4
JournalClinical nuclear medicine
Issue number3
StatePublished - 1991
Externally publishedYes


Dive into the research topics of 'Quantitative I-123-IMP brain SPECT and neuropsychological testing in AIDS dementia'. Together they form a unique fingerprint.

Cite this