Quantitative flow measurements in bioreactors by nuclear magnetic resonance imaging

Bruce E. Hammer, Carole A. Heath, Scott D. Mirer, Georges Belfort

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

We have developed nuclear magnetic resonance (NMR) flow imaging techniques to measure fluid flow in a cell-free hollow fiber bioreactor (HFBR). Using 1H NMR we track the motion of protons and obtain velocity distributions as a function of position and time. These measurements enable the visualization of flow patterns needed for module design and for establishing desired operating conditions. Uneven flow in the cell-containing region of an HFBR can result in concentration gradients and uneven cell distribution that may lead to reduced cell viability. Results from this non-invasive method could be used to design more efficient cell bioreactors or membrane separation devices.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalBio/Technology
Volume8
Issue number4
DOIs
StatePublished - Apr 1990

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

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