Quantifying the selectivity of protein−protein and small molecule interactions with fluorinated tandem bromodomain reader proteins

Keyphrases

• Bromodomain 100%
• Fluorinated 100%
• Small Molecule Interactions 100%
• Reader Protein 100%
• Inhibitor Discovery 33%
• Bromodomain-containing Protein 4 (BRD4) 33%
• Gene Expression 16%
• Protein Concentration 16%
• Small Molecules 16%
• Gene Regulation 16%
• Selective Inhibitor 16%
• Discovery Process 16%
• Enzymatic Activity 16%
• Fragment Screening 16%
• Fluorine NMR 16%
• Multi-domain 16%
• Binding Site 16%
• NMR Techniques 16%
• Binding Interaction 16%
• Low Protein 16%
• Transcription Machinery 16%
• Selective Inhibition 16%
• Chromatin Binding 16%
• Transcription Factor Interaction 16%
• Selectivity Profile 16%
• Bromodomain Inhibitors 16%
• Acetylated Histone 16%
• Disease Regulation 16%
• Bromodomain-containing Protein 16%
• Protein-observed NMR 16%
• First Application 16%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Bromodomain 100%
• BRD4 25%
• BRDT 25%
• Histone 12%
• Gene Expression 12%
• Gene Control 12%
• Enzyme Activity 12%
• Binding Site 12%
• C-Terminus 12%
• Transcription Factors 12%
• Nucleosome 12%