Quantification of turbulence intensity in patients with symptomatic carotid atherosclerosis: A pilot study

Meghan L. Thorne, Richard N. Rankin, Tamie L. Poepping, David W. Holdsworth

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The most widely performed test for patients suspected of having carotid atherosclerosis is Doppler ultrasound (DUS). Unfortunately, limitations in sensitivity and specificity prevent DUS from being the sole diagnostic tool. Novel DUS velocity-derived parameters, such as turbulence intensity (TI), may provide enhanced hemodynamic information within the carotid artery, increasing diagnostic accuracy. In this study, we evaluate a new technique for recording, storing and analyzing DUS in a clinical environment, and determine the correlation between TI and conventional DUS measurements. We have recruited 32 patients with a mean age of 69±11 yrs. An MP3 recorder was used to digitally record Doppler audio signals three times at three sites: the common carotid artery, peak stenosis and region of maximum turbulence. A Fourier-based technique was used to calculate TI, facilitating clinical application without additional ECGgating data. TI was calculated as the standard deviation of Fourier-filtered mean velocity data. We found that TI and clinical PSV were linearly dependent (P<0.001) within the region of maximum turbulence and the precision of all TI measurements was found to be 14%. We have demonstrated the ability to record Doppler waveform data during a conventional carotid exam, and apply off-line custom analysis to Doppler velocity data to produce measurements of TI.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2010 - Ultrasonic Imaging, Tomography, and Therapy
DOIs
StatePublished - Sep 24 2010
EventMedical Imaging 2010 - Ultrasonic Imaging, Tomography, and Therapy - San Diego, CA, United States
Duration: Feb 14 2010Feb 15 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7629
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2010 - Ultrasonic Imaging, Tomography, and Therapy
CountryUnited States
CitySan Diego, CA
Period2/14/102/15/10

Keywords

  • Atherosclerotic carotid artery disease
  • advanced spectral analysis
  • high-pass frequency filter
  • in vivo
  • turbulence intensity

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