Quantification of pial collateral pressure in acute large vessel occlusion stroke: basic concept with patient outcomes

Rizwan A. Tahir, Muhammad Affan, Horia Marin, Sameah A. Haider, Owais Khadem Alsrouji, Ayesha Ahmad, Alex Bou Chebl, Angelos Katramados, Meredith Van Harn, Max Kole

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Pial collateral perfusion to the ischemic penumbra plays a critical role in determining patient outcomes in acute stroke. We aimed to assess the validity and reliability of an intra-procedural technique for measuring and quantifying the pial collateral pressure (QPCP) to ischemic brain tissue during acute stroke secondary to LVO. QPCP measurements were correlated with standard computed tomography angiography (CTA) and digital subtraction angiography imaging assessments of pial collateral perfusion and outcomes after mechanical endovascular revascularization (MER). Methods: This prospective cohort study included 60 consecutive patients with middle cerebral artery (MCA)–M1 and proximal M2 occlusions. QPCP measurements were obtained during MER. The validity of QPCP measurements was evaluated using four widely accepted collateral grading scales. QPCP measurements were also analyzed as a predictor of patient outcomes utilizing National Institute of Health Stroke Scale reduction at 24 h and modified Rankin Scale (mRS) scores at 30 days. Results: QPCP measurements and QPCP ratio (QPCP/systemic mean arterial blood pressure) showed a statistically significant association with single-phase pretreatment CTA Maas and American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology binary grading scales. Patient outcomes demonstrated for every 10-unit increase in QPCP, the odds of mRS 0-2 at 30 days increased by 76% (p = 0.019). Conclusion: QPCP measurements related best with the pretreatment CTA Maas collateral grading scale but were more strongly associated with patient outcomes than any of the four widely accepted collateral grading scales. Greater QPCP was significantly associated with better overall patient outcomes as defined by mRS at 30 days.

Original languageEnglish (US)
Pages (from-to)1313-1323
Number of pages11
JournalNeuroradiology
Volume63
Issue number8
Early online dateJan 28 2021
DOIs
StatePublished - Aug 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.

Keywords

  • Large vessel occlusion
  • Patient outcomes
  • Pial collateral flow
  • Stroke
  • Thrombectomy

PubMed: MeSH publication types

  • Journal Article

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