Quantification of marrow hematogones following autologous stem cell transplant in adult patients with plasma cell myeloma or diffuse large B-cell lymphoma and correlation with outcome

Victor J Santiago, Aleksandr Lazaryan, Brian L McClune, Robert W. McKenna, Elizabeth L Courville

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In this retrospective study, we quantified the hematogone (normal B-lineage precursor) population by flow cytometric immunophenotyping in post-transplant bone marrow biopsy specimens from adult patients who received an autologous stem cell transplant for either plasma cell myeloma (n = 57) or diffuse large B-cell lymphoma (n = 73). The majority of patients (80%) had <5% marrow hematogones post-transplant. Extreme (>10%) hematogone percentages were quite rare, seen in only four patients, and were not associated with disease progression. There was a positive association between the post-transplant day and hematogone percentage within the first year after transplant, and a negative association thereafter. Plasma cell myeloma patients with ≥5% hematogones in any post-transplant flow cytometry study had a worse overall survival as did plasma cell myeloma patients with increased hematogones (as defined by percentile) at 100 days post-transplant. These findings require further study, ideally in a prospective study design.

Original languageEnglish (US)
Pages (from-to)958-966
Number of pages9
JournalLeukemia and Lymphoma
Volume59
Issue number4
DOIs
StatePublished - Jul 24 2018

    Fingerprint

Keywords

  • Autologous stem cell transplant
  • Autotransplant
  • B-lineage precursors
  • Diffuse large B-cell lymphoma
  • Hematogones
  • Multiple myeloma
  • Plasma cell myeloma

PubMed: MeSH publication types

  • Journal Article

Cite this