Quantification of in vivo ³¹P NMR brain spectra using LCModel

Quantification of ³¹P NMR spectra is commonly performed using line-fitting techniques with prior knowledge. Currently available time- and frequency-domain analysis software includes AMARES (in jMRUI) and CFIT respectively. Another popular frequency-domain approach is LCModel, which has been successfully used to fit both ¹H and ¹³C in vivo NMR spectra. To the best of our knowledge LCModel has not been used to fit ³¹P spectra. This study demonstrates the feasibility of using LCModel to quantify in vivo ³¹P MR spectra, provided that adequate prior knowledge and LCModel control parameters are used. Both single-voxel and MRSI data are presented, and similar results are obtained with LCModel and with AMARES. This provides a new method for automated, operator-independent analysis of ³¹P NMR spectra.