Quantification of crystallinity in blends of lyophilized and crystalline MK-0591 using x-ray powder diffraction

S. D. Clas; R. Faizer; R. E. O'Connor; E. B. Vadas

doi:10.1016/0378-5173(95)00008-7

Quantification of crystallinity in blends of lyophilized and crystalline MK-0591 using x-ray powder diffraction

S. D. Clas, R. Faizer, R. E. O'Connor, E. B. Vadas

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

X-ray powder diffraction was used to determine the percent crystallinity in blends of crystalline and X-ray amorphous MK-0591, a potent indirect leukotriene biosynthesis inhibitor. A linear calibration curve was obtained. Preliminary studies using powder blends of MK-0591 with pregelatinized starch, microcrystalline cellulose, and magnesium stearate demonstrated the feasibility of using this method to determine (or quantify) the percent crystallinity of MK-0591 in tablet formulations.

Original language	English (US)
Pages (from-to)	73-79
Number of pages	7
Journal	International journal of pharmaceutics
Volume	121
Issue number	1
DOIs	https://doi.org/10.1016/0378-5173(95)00008-7
State	Published - Jul 6 1995
Externally published	Yes

Keywords

708
Crystallinity
L-686
Leukotriene biosynthesis inhibitor
MK-0591
X-ray powder diffraction
quantitative determination

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10.1016/0378-5173(95)00008-7

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title = "Quantification of crystallinity in blends of lyophilized and crystalline MK-0591 using x-ray powder diffraction",

abstract = "X-ray powder diffraction was used to determine the percent crystallinity in blends of crystalline and X-ray amorphous MK-0591, a potent indirect leukotriene biosynthesis inhibitor. A linear calibration curve was obtained. Preliminary studies using powder blends of MK-0591 with pregelatinized starch, microcrystalline cellulose, and magnesium stearate demonstrated the feasibility of using this method to determine (or quantify) the percent crystallinity of MK-0591 in tablet formulations.",

keywords = "708, Crystallinity, L-686, Leukotriene biosynthesis inhibitor, MK-0591, X-ray powder diffraction, quantitative determination",

author = "Clas, \{S. D.\} and R. Faizer and O'Connor, \{R. E.\} and Vadas, \{E. B.\}",

year = "1995",

month = jul,

day = "6",

doi = "10.1016/0378-5173(95)00008-7",

language = "English (US)",

volume = "121",

pages = "73--79",

journal = "International journal of pharmaceutics",

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TY - JOUR

T1 - Quantification of crystallinity in blends of lyophilized and crystalline MK-0591 using x-ray powder diffraction

AU - Clas, S. D.

AU - Faizer, R.

AU - O'Connor, R. E.

AU - Vadas, E. B.

PY - 1995/7/6

Y1 - 1995/7/6

N2 - X-ray powder diffraction was used to determine the percent crystallinity in blends of crystalline and X-ray amorphous MK-0591, a potent indirect leukotriene biosynthesis inhibitor. A linear calibration curve was obtained. Preliminary studies using powder blends of MK-0591 with pregelatinized starch, microcrystalline cellulose, and magnesium stearate demonstrated the feasibility of using this method to determine (or quantify) the percent crystallinity of MK-0591 in tablet formulations.

AB - X-ray powder diffraction was used to determine the percent crystallinity in blends of crystalline and X-ray amorphous MK-0591, a potent indirect leukotriene biosynthesis inhibitor. A linear calibration curve was obtained. Preliminary studies using powder blends of MK-0591 with pregelatinized starch, microcrystalline cellulose, and magnesium stearate demonstrated the feasibility of using this method to determine (or quantify) the percent crystallinity of MK-0591 in tablet formulations.

KW - 708

KW - Crystallinity

KW - L-686

KW - Leukotriene biosynthesis inhibitor

KW - MK-0591

KW - X-ray powder diffraction

KW - quantitative determination

UR - https://www.scopus.com/pages/publications/0029039763

UR - https://www.scopus.com/inward/citedby.url?scp=0029039763&partnerID=8YFLogxK

U2 - 10.1016/0378-5173(95)00008-7

DO - 10.1016/0378-5173(95)00008-7

M3 - Article

AN - SCOPUS:0029039763

SN - 0378-5173

VL - 121

SP - 73

EP - 79

JO - International journal of pharmaceutics

JF - International journal of pharmaceutics

IS - 1

ER -

Quantification of crystallinity in blends of lyophilized and crystalline MK-0591 using x-ray powder diffraction

Abstract

Keywords

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