Quantification of crystallinity in blends of lyophilized and crystalline MK-0591 using x-ray powder diffraction

S. D. Clas, R. Faizer, R. E. O'Connor, E. B. Vadas

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

X-ray powder diffraction was used to determine the percent crystallinity in blends of crystalline and X-ray amorphous MK-0591, a potent indirect leukotriene biosynthesis inhibitor. A linear calibration curve was obtained. Preliminary studies using powder blends of MK-0591 with pregelatinized starch, microcrystalline cellulose, and magnesium stearate demonstrated the feasibility of using this method to determine (or quantify) the percent crystallinity of MK-0591 in tablet formulations.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalInternational journal of pharmaceutics
Volume121
Issue number1
DOIs
StatePublished - Jul 6 1995
Externally publishedYes

Keywords

  • 708
  • Crystallinity
  • L-686
  • Leukotriene biosynthesis inhibitor
  • MK-0591
  • X-ray powder diffraction
  • quantitative determination

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