Quantiative importance of dietary constituents other than glucose as insulin secretagogues in type II diabetes

F. Q. Nuttall, M. C. Gannon

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

In seven type II (non-insulin-dependent) diabetic patients, given either 50 g glucose or a mixed meal potentially containing 61 g glucose as starch and sucrose, the postmeal plasma glucose area integrated over 4 h was less after the mixed meal. The insulin area was considerably greater (2.1-fold). The greater increase in insulin could be explained largely, but not entirely, by the protein and fructose in the mixed meal (85%) which, in addition to glucose, are known insulin secretagogues. The residual unexplained increase may be due to a synergistic interaction of these secretagogues, an unidentified insulin secretagogue, or by a reduced insulin removal rate. These possibilities remain to be explored.

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalDiabetes care
Volume11
Issue number1
DOIs
StatePublished - Jan 1 1988

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