Quality of life for men with metastatic castrate-resistant prostate cancer participating in an aerobic and resistance exercise pilot intervention

Crystal S. Langlais, Yea Hung Chen, Erin L. Van Blarigan, June M. Chan, Charles J. Ryan, Li Zhang, Hala T. Borno, Robert U. Newton, Anthony Luke, Alexander S. Bang, Neil Panchal, Imelda Tenggara, Brooke Schultz, Emil Lavaki, Nicole Pinto, Rahul Aggarwal, Terence Friedlander, Vadim S. Koshkin, Andrea L. Harzstark, Eric J. SmallStacey A. Kenfield

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Following a prostate cancer diagnosis, disease and treatment-related symptoms may result in diminished quality of life (QoL). Whether exercise improves QoL in men with metastatic castrate-resistant prostate cancer (mCRPC) is not fully understood. Methods: We conducted a 3-arm pilot randomized controlled trial to assess the feasibility, acceptability, safety, and efficacy of a 12-week remotely monitored exercise program among men with mCRPC. Here we report qualitative changes in QoL, consistent with the guidelines for pilot trials. Men were randomized to control, aerobic exercise, or resistance exercise. Exercise prescriptions were based on baseline cardiorespiratory and strength assessments. QoL outcomes were evaluated using self-reported questionnaires (e.g., QLQ-C30, PROMIS Fatigue, Pittsburgh Sleep Quality Index (PSQI), EPIC-26) collected at baseline and 12 weeks. Results: A total of 25 men were randomized (10 control, 8 aerobic, 7 resistance). Men were predominately white (76%) with a median age of 71 years (range: 51–84) and 10.5 years (range: 0.9–26.3) post prostate cancer diagnosis. The men reported poor sleep quality and high levels of fatigue at enrollment. Other baseline QoL metrics were relatively high. Compared to the controls at 12 weeks, the resistance arm reported some improvements in social function and urinary irritative/obstruction symptoms while the aerobic arm reported some improvements in social function and urinary incontinence, yet worsening nausea/vomiting. Compared to the resistance arm, the aerobic arm reported worse urinary irritative/obstruction symptoms and self-rated QoL, yet some improvements in emotional function, insomnia, and diarrhea. Conclusions: The 3-month exercise intervention pilot appeared to have modest effects on QoL among mCRPC survivors on ADT. Given the feasibility, acceptability, and safety demonstrated in prior analyses, evaluation of the effect of the intervention on QoL in a larger sample and for extended duration may still be warranted.

Original languageEnglish (US)
Pages (from-to)146.e1-146.e11
JournalUrologic Oncology: Seminars and Original Investigations
Issue number3
StatePublished - Mar 2023

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health : R21CA184605 (SAK, JMC); K07CA197077 (EVB); F31CA247093 (CSL). The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Institutes of Health.

Publisher Copyright:
© 2022 The Authors


  • Behavioral intervention: Physical activity
  • Remote
  • Strength training

PubMed: MeSH publication types

  • Randomized Controlled Trial
  • Journal Article
  • Research Support, N.I.H., Extramural


Dive into the research topics of 'Quality of life for men with metastatic castrate-resistant prostate cancer participating in an aerobic and resistance exercise pilot intervention'. Together they form a unique fingerprint.

Cite this