TY - JOUR
T1 - Quality of life assessment among HIV-positive persons entering the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial
AU - Lifson, Ar
AU - Grandits, Ga
AU - Gardner, Em
AU - Wolff, Mj
AU - Pulik, P.
AU - Williams, I.
AU - Burman, Wj
AU - International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Group
N1 - Publisher Copyright:
© 2015 British HIV Association.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Objectives: With HIV treatment prolonging survival and HIV infection now managed as a chronic illness, quality of life (QOL) is important to evaluate in persons living with HIV (PLWH). We assessed at study entry the QOL of antiretroviral-naïve PLWH with CD4 counts >500 cells/μL in the Strategic Timing of AntiRetroviral Treatment (START) clinical trial. Methods: QOL was assessed with: (1) a visual analogue scale (VAS) for self-assessment of overall current health; (2) the Short-Form 12-Item Version 2 Health Survey® (SF-12V2), for which responses are summarized into eight individual QOL domains plus component summary scores for physical health [the Physical Health Component Summary (PCS)] and mental health [the Mental Health Component Summary (MCS)]. The VAS and eight domain scores were scaled from 0 to 100. Mean QOL measures were calculated overall and by demographic, clinical and behavioural factors. Results: A total of 4631 participants completed the VAS and 4119 the SF-12. The mean VAS score (with standard deviation) was 80.9±15.7. Mean SF-12 domain scores were lowest for vitality (66.3±26.4) and mental health (68.6±21.4), and highest for physical functioning (89.3±23.0) and bodily pain (88.0±21.4). Using multiple linear regression, PCS scores were lower (P<0.001) for Asians, North Americans, female participants, older participants, and those with less education, longer duration of known HIV infection, alcoholism/substance dependence and body mass index ≥30kg/m2. MCS scores were highest (P<0.001) for Africans, South Americans and older participants, and lowest for female participants, current smokers and those with alcoholism/substance dependence. Conclusions: In this primarily healthy population, QOL was mostly favourable, emphasizing that it is important that HIV treatments do not negatively impact QOL. Self-assessed physical health summary scores were higher than mental health scores. Factors such as older age and geographical region had different effects on perceived physical and mental health.
AB - Objectives: With HIV treatment prolonging survival and HIV infection now managed as a chronic illness, quality of life (QOL) is important to evaluate in persons living with HIV (PLWH). We assessed at study entry the QOL of antiretroviral-naïve PLWH with CD4 counts >500 cells/μL in the Strategic Timing of AntiRetroviral Treatment (START) clinical trial. Methods: QOL was assessed with: (1) a visual analogue scale (VAS) for self-assessment of overall current health; (2) the Short-Form 12-Item Version 2 Health Survey® (SF-12V2), for which responses are summarized into eight individual QOL domains plus component summary scores for physical health [the Physical Health Component Summary (PCS)] and mental health [the Mental Health Component Summary (MCS)]. The VAS and eight domain scores were scaled from 0 to 100. Mean QOL measures were calculated overall and by demographic, clinical and behavioural factors. Results: A total of 4631 participants completed the VAS and 4119 the SF-12. The mean VAS score (with standard deviation) was 80.9±15.7. Mean SF-12 domain scores were lowest for vitality (66.3±26.4) and mental health (68.6±21.4), and highest for physical functioning (89.3±23.0) and bodily pain (88.0±21.4). Using multiple linear regression, PCS scores were lower (P<0.001) for Asians, North Americans, female participants, older participants, and those with less education, longer duration of known HIV infection, alcoholism/substance dependence and body mass index ≥30kg/m2. MCS scores were highest (P<0.001) for Africans, South Americans and older participants, and lowest for female participants, current smokers and those with alcoholism/substance dependence. Conclusions: In this primarily healthy population, QOL was mostly favourable, emphasizing that it is important that HIV treatments do not negatively impact QOL. Self-assessed physical health summary scores were higher than mental health scores. Factors such as older age and geographical region had different effects on perceived physical and mental health.
KW - Antiretroviral therapy
KW - HIV
KW - Quality of life
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U2 - 10.1111/hiv.12237
DO - 10.1111/hiv.12237
M3 - Article
C2 - 25711327
AN - SCOPUS:84923321049
SN - 1464-2662
VL - 16
SP - 88
EP - 96
JO - HIV Medicine
JF - HIV Medicine
IS - S1
ER -