Quadratic pulse inversion ultrasonic imaging (QPI): Detection of low-level harmonic activity of microbubble contrast agents

Mamoun F. Al-Mistarihi, Emad S. Ebbini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

We present an ultrasonic imaging approach that combines harmonic-sensitive pulse sequences with a post-beamforming quadratic kernel derived from a second-order Volterra filter (SOVF). This approach is designed to produce images with high sensitivity to nonlinear oscillations (20 - 30 dB below the fundamental) from microbubble ultrasound contrast agents (UCA) while maintaining high levels of noise rejection. In this paper, we demonstrate the performance of this approach with pulse-inversion imaging sequence consisting of two transmit pulses with opposite polarity whose echoes are summed to enhance the even harmonics and suppress the fundamental. This is followed by an optimally designed SOVF-based quadratic kernel for further enhancing the harmonic signals, while maximizing the noise rejection. The approach is demonstrated experimentally using images from in vivo kidney after bolus injection with UCA. Imaging results as well as the spectral contents of QPI data show a significant increase in harmonic sensitivity and reduction in noise levels. Implications of this approach on new forms of functional ultrasound imaging are discussed.

Original languageEnglish (US)
Title of host publication2005 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP '05 - Proceedings - Image and Multidimensional Signal Processing Multimedia Signal Processing
PagesII1009-II1012
DOIs
StatePublished - Dec 1 2005
Event2005 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP '05 - Philadelphia, PA, United States
Duration: Mar 18 2005Mar 23 2005

Publication series

NameICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
VolumeII
ISSN (Print)1520-6149

Other

Other2005 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP '05
Country/TerritoryUnited States
CityPhiladelphia, PA
Period3/18/053/23/05

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