Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Curtis C. Hughey; Peter A. Crawford

doi:10.1016/j.cmet.2019.05.013

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Research output: Contribution to journal › Short survey › peer-review

Abstract

Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

Original language	English (US)
Pages (from-to)	1236-1238
Number of pages	3
Journal	Cell Metabolism
Volume	29
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2019.05.013
State	Published - Jun 4 2019

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© 2019 Elsevier Inc.

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title = "Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword",

abstract = "Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.",

author = "Hughey, \{Curtis C.\} and Crawford, \{Peter A.\}",

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year = "2019",

month = jun,

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doi = "10.1016/j.cmet.2019.05.013",

language = "English (US)",

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T1 - Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

AU - Hughey, Curtis C.

AU - Crawford, Peter A.

PY - 2019/6/4

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N2 - Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

AB - Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

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UR - https://www.scopus.com/pages/publications/85066282712#tab=citedBy

U2 - 10.1016/j.cmet.2019.05.013

DO - 10.1016/j.cmet.2019.05.013

M3 - Short survey

C2 - 31167118

AN - SCOPUS:85066282712

SN - 1550-4131

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JO - Cell Metabolism

JF - Cell Metabolism

IS - 6

ER -

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Abstract

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