Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

Original languageEnglish (US)
Pages (from-to)1236-1238
Number of pages3
JournalCell Metabolism
Issue number6
StatePublished - Jun 4 2019

Bibliographical note

Funding Information:
This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases grant DK091538 (P.A.C.).

Publisher Copyright:
© 2019 Elsevier Inc.


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