Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.
Bibliographical noteFunding Information:
This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases grant DK091538 (P.A.C.).
© 2019 Elsevier Inc.