Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Research output: Contribution to journalShort survey


Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

Original languageEnglish (US)
Pages (from-to)1236-1238
Number of pages3
JournalCell Metabolism
Issue number6
StatePublished - Jun 4 2019


PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Comment

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