Abstract
Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.
Original language | English (US) |
---|---|
Pages (from-to) | 1236-1238 |
Number of pages | 3 |
Journal | Cell Metabolism |
Volume | 29 |
Issue number | 6 |
DOIs | |
State | Published - Jun 4 2019 |
Bibliographical note
Publisher Copyright:© 2019 Elsevier Inc.