Putting the brakes on a myosin motor

Casey Eddington, Margaret A. Titus

Research output: Contribution to journalReview articlepeer-review


Insulin-stimulated trafficking of GLUT4 requires the myosin motor Myo1C and signaling adaptor 14-3-3β. Originally, it was thought that 14-3-3β promotes GLUT4 transport by binding the Myo1C lever arm and activating the Myo1C motor. New work by Ji and Ostap using in vitro assays reveals that 14-3-3β binding actually inhibits Myo1C motility, prompting reconsideration of the functional relationship between 14-3-3β and Myo1C and the regulatory potential of atypical light chains.

Original languageEnglish (US)
Pages (from-to)3757-3758
Number of pages2
JournalJournal of Biological Chemistry
Issue number12
StatePublished - Mar 20 2020

Bibliographical note

Funding Information:
This work is supported by National Institutes of Health Grants R01GM122917 and R01GM122917-01S1. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the respon-sibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2020 Eddington and Titus. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.


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