Abstract
Insulin-stimulated trafficking of GLUT4 requires the myosin motor Myo1C and signaling adaptor 14-3-3β. Originally, it was thought that 14-3-3β promotes GLUT4 transport by binding the Myo1C lever arm and activating the Myo1C motor. New work by Ji and Ostap using in vitro assays reveals that 14-3-3β binding actually inhibits Myo1C motility, prompting reconsideration of the functional relationship between 14-3-3β and Myo1C and the regulatory potential of atypical light chains.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3757-3758 |
| Number of pages | 2 |
| Journal | Journal of Biological Chemistry |
| Volume | 295 |
| Issue number | 12 |
| DOIs | |
| State | Published - Mar 20 2020 |
Bibliographical note
Publisher Copyright:© 2020 Eddington and Titus. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.