Abstract
Insulin-stimulated trafficking of GLUT4 requires the myosin motor Myo1C and signaling adaptor 14-3-3β. Originally, it was thought that 14-3-3β promotes GLUT4 transport by binding the Myo1C lever arm and activating the Myo1C motor. New work by Ji and Ostap using in vitro assays reveals that 14-3-3β binding actually inhibits Myo1C motility, prompting reconsideration of the functional relationship between 14-3-3β and Myo1C and the regulatory potential of atypical light chains.
Original language | English (US) |
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Pages (from-to) | 3757-3758 |
Number of pages | 2 |
Journal | Journal of Biological Chemistry |
Volume | 295 |
Issue number | 12 |
DOIs | |
State | Published - Mar 20 2020 |
Bibliographical note
Funding Information:This work is supported by National Institutes of Health Grants R01GM122917 and R01GM122917-01S1. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the respon-sibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2020 Eddington and Titus. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Comment