Putting our heads together: A consensus approach to brain/non-brain segmentation in T1-weighted MR volumes

Kelly Rehm, Kirt Schaper, Jon Anderson, Roger Woods, Sarah Stoltzner, David Rottenberg

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

We describe an approach to brain extraction from T1-weighted MR volumes that uses a hierarchy of masks created by different models to form a consensus mask. The algorithm (McStrip) incorporates atlas-based extraction via nonlinear warping, intensity-threshold masking with connectivity constraints, and edge-based masking with morphological operations. Volume and boundary metrics were computed to evaluate the reproducibility and accuracy of McStrip against manual brain extraction on 38 scans from normal and ataxic subjects. McStrip masks were reproducible across six repeat scans of a normal subject and were significantly more accurate than the masks produced by any of the individual algorithmic components.

Original languageEnglish (US)
Pages (from-to)1262-1270
Number of pages9
JournalNeuroImage
Volume22
Issue number3
DOIs
StatePublished - Jul 1 2004

Keywords

  • Algorithm
  • Brain
  • MR volume

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