TY - JOUR
T1 - Putting on the gas and taking off the brakes
T2 - A novel combinatorial strategy to enhance tumor-infiltrating lymphocytes
AU - Felices, Martin
AU - Miller, Jeffrey S.
N1 - Publisher Copyright:
© 2021 American Association for Cancer Research.
PY - 2021/10
Y1 - 2021/10
N2 - The advent of checkpoint blockade and use of cytokines to enhance immune responses have changed the field of immunotherapy. Yet, these approaches are not without drawbacks including systemic toxicities and acquired therapeutic resistance. In this issue, Xu and colleagues describe a novel biological molecule composed of a PD-1-targeting antibody linked to a mutated IL15 that induces better targeting of IL15 to tumor-infiltrating lymphocytes (TIL) to decrease systemic toxicities and enhance antitumor responses.
See related article by Xu et al., p. 1141 (1).
AB - The advent of checkpoint blockade and use of cytokines to enhance immune responses have changed the field of immunotherapy. Yet, these approaches are not without drawbacks including systemic toxicities and acquired therapeutic resistance. In this issue, Xu and colleagues describe a novel biological molecule composed of a PD-1-targeting antibody linked to a mutated IL15 that induces better targeting of IL15 to tumor-infiltrating lymphocytes (TIL) to decrease systemic toxicities and enhance antitumor responses.
See related article by Xu et al., p. 1141 (1).
UR - http://www.scopus.com/inward/record.url?scp=85118097523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85118097523&partnerID=8YFLogxK
U2 - 10.1158/2326-6066.CIR-21-0556
DO - 10.1158/2326-6066.CIR-21-0556
M3 - Article
C2 - 34493487
AN - SCOPUS:85118097523
SN - 2326-6066
VL - 9
SP - 1110
JO - Cancer Immunology Research
JF - Cancer Immunology Research
IS - 10
ER -