Putative blood pressure overswinging, circadian hyper-amplitude-tension (CHAT), in type 2 diabetes

V. R.C. Gonzalez, S. Sanchez De La Pena, J. Siegelová, H. Svačinová, G. Cornelissen, S. Zhou, J. Holte, G. S. Katinas, F. Halberg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Within the scope of an international project of the Biosphere and the Cosmos (BIOCOS) focusing on stroke prevention, a population of Mexican patients was screened. Each subject's blood pressure and heart rate were measured around the clock by ambulatory monitoring for 24 h. The subject group primarily consisted of patients with non-insulin-dependent diabetes mellitus (NIDDM). Each profile was assessed by sphygmochron, consisting of a parametric approach wherein a 2-component model was fitted to the data, complemented by a non-parametric approach wherein the patient's profile was compared by computer with reference limits specified as a function of time, gender and age. CHAT (circadian hyper-amplitude-tension), a condition characterised by an excessive circadian amplitude of blood pressure, was found.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Issue number3
StatePublished - 2002


  • Blood pressure overswinging
  • Circadian hyper-amplitude-tension (CHAT)
  • Type 2 diabetes mellitus


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