Pushing spatial and temporal resolution for functional and diffusion MRI in the Human Connectome Project

Kamil Uǧurbil, Junqian Xu, Edward J. Auerbach, Steen Moeller, An T. Vu, Julio M. Duarte-Carvajalino, Christophe Lenglet, Xiaoping Wu, Sebastian Schmitter, Pierre Francois Van de Moortele, John Strupp, Guillermo Sapiro, Federico De Martino, Dingxin Wang, Noam Harel, Michael Garwood, Liyong Chen, David A. Feinberg, Stephen M. Smith, Karla L. MillerStamatios N. Sotiropoulos, Saad Jbabdi, Jesper L R Andersson, Timothy E J Behrens, Matthew F. Glasser, David C. Van Essen, Essa Yacoub

Research output: Contribution to journalArticlepeer-review

586 Scopus citations


The Human Connectome Project (HCP) relies primarily on three complementary magnetic resonance (MR) methods. These are: 1) resting state functional MR imaging (rfMRI) which uses correlations in the temporal fluctuations in an fMRI time series to deduce '. functional connectivity'; 2) diffusion imaging (dMRI), which provides the input for tractography algorithms used for the reconstruction of the complex axonal fiber architecture; and 3) task based fMRI (tfMRI), which is employed to identify functional parcellation in the human brain in order to assist analyses of data obtained with the first two methods. We describe technical improvements and optimization of these methods as well as instrumental choices that impact speed of acquisition of fMRI and dMRI images at 3. T, leading to whole brain coverage with 2. mm isotropic resolution in 0.7. s for fMRI, and 1.25. mm isotropic resolution dMRI data for tractography analysis with three-fold reduction in total dMRI data acquisition time. Ongoing technical developments and optimization for acquisition of similar data at 7. T magnetic field are also presented, targeting higher spatial resolution, enhanced specificity of functional imaging signals, mitigation of the inhomogeneous radio frequency (RF) fields, and reduced power deposition. Results demonstrate that overall, these approaches represent a significant advance in MR imaging of the human brain to investigate brain function and structure.

Original languageEnglish (US)
Pages (from-to)80-104
Number of pages25
StatePublished - Oct 15 2013

Bibliographical note

Funding Information:
The work reported in this article was supported by the Human Connectome Project ( 1U54MH091657 ) from the 16 Institutes and Centers of the National Institutes of Health that support the NIH Blueprint for Neuroscience Research and by the Biotechnology Research Center (BTRC) grant P41 EB015894 from NIBIB , and NINDS Institutional Center Core Grant P30 NS076408 .

Funding Information:
A 10.5 T system, funded by NIH grants other than HCP and non-NIH sources, is being developed in CMRR. This system is currently delayed due to world-wide helium shortages. Should it become operational within the funding period of the current HCP initiative, it will be explored for HCP studies as well.


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