Purinergic signalling in the kidney in health and disease

Geoffrey Burnstock, Louise C. Evans, Matthew A. Bailey

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine- and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.

Original languageEnglish (US)
Pages (from-to)71-101
Number of pages31
JournalPurinergic Signalling
Volume10
Issue number1
DOIs
StatePublished - Mar 2014
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments The authors are very grateful to Dr Gillian E. Knight for her invaluable assistance in the preparation of this review article. The University/British Heart Foundation Centre for Cardiovascular Science is funded by The British Heart Foundation, Kidney Research UK.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • ATP release
  • Diabetes
  • Glomerulus
  • Kidney failure
  • Sodium transport
  • Tubules

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