Pulsing gels for episodic drug delivery: Autonomous chemomechanical feedback oscillations in a gel/enzyme system

Ronald A Siegel, Gauri P. Misra

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

A gel/enzyme device was constructed in an effort to mimic the periodic, pulsatile endogenous release of hormones. The swelling and permeability of the device to hormones exhibits regular autonomous pulsations. The device functions by negative feedback, with hysteresis, between a mechanical system which regulates the availability of endogenous glucose the enzyme glucose oxidase, and chemical system which produces protons which bind reversibly to the gel and hence alter the gel's swelling and permeability to glucose.

Original languageEnglish (US)
Pages (from-to)705-706
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume41
Issue number1
StatePublished - Mar 1 2000
EventThe San Francisco Meeting - San Francisco, CA, USA
Duration: Mar 26 2000Mar 31 2000

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