Pulsed dye laser therapy for sun damaged skin

Brian D. Zelickson, Suzanne L. Kilmer, Eric Bernstein, Vera A. Chotzen, Jayson Dock, David Mehregan, Charlotte Coles

Research output: Contribution to journalArticlepeer-review

228 Scopus citations


Objective: The objective of this study was to evaluate the effectiveness of the pulsed dye laser (585 nm, 450 ms) in the treatment of sun induced wrinkles. Design: Patients had one pulsed dye laser (585 nm) treatment. The treated areas were assessed by the following methods: grading of skin wrinkles at 6 weeks, 12 weeks, and 6-14 months after treatment by blinded observers and by light and electron microscopy. Setting: An ambulatory care center at Abbott Northwestern Hospital (ANH) and the Laser and Skin Surgery Center of Northern California (LSSCNC). Patients: Twenty patients were treated, half with mild to moderate and half with moderate to severe sun induced skin wrinkles. Results: At last follow up 90% (9/10) of the mild to moderate wrinkles and 40% (4/10) of the treated patients with moderate to severe wrinkles had clinically observable improvement in their sun induced skin wrinkles. Histologic examinations of the treated areas showed a superficial dermal band of well organized elastin and collagen fibers replacing pre-treatment elastic tissue. Increased cellularity and mucin deposition was consistent with dermal collagen remodeling.

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalLasers in Surgery and Medicine
Issue number3
StatePublished - Oct 14 1999


  • Pulsed dye laser
  • Skin
  • Wrinkles


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